BACKGROUND AND PURPOSE Bacterial lipopolysaccharide (LPS), an endotoxin, has been reported to induce the expression of inducible isoforms of both nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) in various cell types. LPS is also known to dilate systemic vasculature, including cerebral vessels. This study aimed to determine to what extent LPS induces iNOS and COX-2 expression in the brai...

background there are hoarding documents for the biological importance of cyclooxygenase-2 (cox-2) in pancreatic carcinogenesis. we aimed to thoroughly investigate the dna sequence variations of whole cox-2 exons in a large case-control study of pancreatic cancer by direct sequencing.   methods the entire exonic regions of cox-2 including 10 exons were sequenced in the germline dna of 96 patient...

a substantial amount of evidence has proposed an important role for cyclooxygenase-2 (cox-2) enzyme in brain diseases and affiliate disorders. the purpose of this research was studying the effects of cox-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and parkinson’s disease (pd). in this study, the effect of acute and sub-chronic oral administration ...

Ibuprofen and aspirin are frequently used to relieve inflammation, pain, fever. These the two most significant non-steroidal anti-inflammatory drugs (NSAIDs). They prevent development of prostaglandin by blockampounds have been assessed ibuprofen as well quantum mechanical computations. Density functional theory (DFT) with B3LYP/6-31G+ basis function has elucidate thermo-chemical, molecular orb...

Interleukin-1beta (IL-1beta) has been implicated in the pathogenesis of inflammatory diseases of the airway. In this study, we investigated the regulation of MUC2 and MUC5AC expression and of their regulatory mechanisms through cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)). Cells activated by IL-1beta showed increased COX-2, MUC2, and MUC5AC expressions at both the mRNA and protein l...