نتایج جستجو برای: cycloguanil pamoate
تعداد نتایج: 304 فیلتر نتایج به سال:
BACKGROUNDS: Occurrence of resistance against antiparasitic drugs has made it essential for researchers to find new sources for antiparasitic drugs. OBJECTIVES: This study was performed to determine the efficiency of alcoholic extract of worm wood (Artemisia absinthium) on Syphasia parasite. METHODS: Artemisia absinthium extract was examined on 3 groups of mice at 2.5%, 5% and 10% concentration...
Discussion Although multiresistant P. faldipamm is an increasing problem, reports of P . vivax resistant to chloroquine have been few. The above case reports document the presence of chloroquine-resistant P. vivax in India, and show that it may not be as rare as it i s presumed to be. Also, the number of drug resistant strains is probably increasing. Antimalarial drugs other than chloroquine us...
WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved antihelmintic drug that inhibits WNT signaling, to test whether pharmacologic inhibition of WNT signaling can specifically target TICs of aggressive breast cancer cells. SUM-149, an inflammatory breast cancer cell line, and SUM-159, a metaplastic ba...
The reduced binding of pyrimethamine to Ser108Asn (S108N) mutants of parasite dihydrofolate reductase (DHFR), which forms the basis of resistance of Plasmodium falciparum to pyrimethamine, is largely due to steric constraint imposed by the bulky side chain of N108 on Cl of the 5-p-Cl-phenyl group. This and other S108 mutants with bulky side chains all showed reduced binding to pyrimethamine and...
Medication non-adherence in patients with schizophrenia continues to be a significant problem and threatens successful treatment outcomes. Medication non-adherence is often associated with negative consequences, including symptom exacerbation, more frequent emergency room visits, re-hospitalizations and relapse. Long-acting injectable (LAI) forms of antipsychotics allow for rapid identification...
Resistance to antifolate antimalarial drugs (cycloguanil, a biologically active metabolite of pioguanil, and pyrimethamine) is associated with a Serto Asn108 point mutation in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparunt. The frequency of this mutation was studied in 127 clinical isolates obtained in Yaounde, Cameroon using a simple and rapid molecular techniq...
backgrounds: occurrence of resistance against antiparasitic drugs has made it essential for researchers to find new sources for antiparasitic drugs. objectives: this study was performed to determine the efficiency of alcoholic extract of worm wood (artemisia absinthium) on syphasia parasite. methods: artemisia absinthium extract was examined on 3 groups of mice at 2.5%, 5% and 10% concentration...
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