نتایج جستجو برای: cyclin b1

تعداد نتایج: 41655  

Journal: :Developmental biology 2010
Kyota Yasuda Tomoya Kotani Ryoma Ota Masakane Yamashita

Temporal translation control of localized mRNA is crucial for regulating various cellular and developmental processes. However, little is known about the mechanisms of temporal translation control of localized mRNA due to the limitation in technology. cyclin B1 mRNA at the animal polar cytoplasm of immature zebrafish oocytes is translationally repressed, and its activation is temporally regulat...

2014
Erik Müllers Helena Silva Cascales Himjyot Jaiswal Adrian T Saurin Arne Lindqvist

Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic inducers, and thus the ability to resume cell division. This permanent cell cycle exit depends on p21, p53, and APC/C(Cdh1). However, when and how pe...

Journal: :Journal of clinical pathology 2005
J Bondi A Husdal G Bukholm J M Nesland A Bakka I R K Bukholm

BACKGROUND/AIMS Deregulation of cell cycle control is a hallmark of cancer. The primary cyclins (A, B1, D1, D3, and E) are crucial for cell cycle progression. Secondary cyclins (C and H) have putative indirect effects on cell cycle progression and have not previously been evaluated in colon cancer. This study examined cyclin protein expression and gene amplification in colon adenocarcinoma and ...

2010
Olivier Gavet Jonathon Pines

The cyclin B-Cdk1 kinase triggers mitosis in most eukaryotes. In animal cells, cyclin B shuttles between the nucleus and cytoplasm in interphase before rapidly accumulating in the nucleus at prophase, which promotes disassembly of the nuclear lamina and nuclear envelope breakdown (NEBD). What triggers the nuclear accumulation of cyclin B1 is presently unclear, although the prevailing view is th...

Journal: :Biochemical and biophysical research communications 2014
Kazuki Takahashi Tomoya Kotani Yoshinao Katsu Masakane Yamashita

In immature zebrafish oocytes, dormant cyclin B1 mRNAs localize to the animal polar cytoplasm as aggregates. After hormonal stimulation, cyclin B1 mRNAs are dispersed and translationally activated, which are necessary and sufficient for the induction of zebrafish oocyte maturation. Besides cytoplasmic polyadenylation element-binding protein (CPEB) and cis-acting elements in the 3' untranslated ...

شهریاری, فرج ا..., عظیمی, اکبر, فتوت, امیر, حاجی زاده, خداورد , کاظمی قلعه, رضا ,

 سابقه و هدف: اثر سمی کادمیوم بر پارامترهای رشدی و تقسیم سلولی در مناطق مریستمی گیاهان مختلف به اثبات رسیده است. اما با وجود این شواهد، مکانیزم های مولکولی دقیق این فرآیند به خوبی شناخته نشده است. هدف از این تحقیق بررسی اثر کادمیوم بر بیان ژنهای cyclin B1 و CDK-A در نوک ریشه گیاهچه های گندم، برای شناخت مکانیزم های مولکولی تاثیر کاهشی کادمیوم بر رشد است.  مواد و روش ها: نوک ریشه گیاهچه های گندم ...

Journal: :Cell 2000
Irina Groisman Yi-Shuian Huang Raul Mendez Quiping Cao William Theurkauf Joel D Richter

In Xenopus development, the expression of several maternal mRNAs is regulated by cytoplasmic polyadenylation. CPEB and maskin, two factors that control polyadenylation-induced translation are present on the mitotic apparatus of animal pole blastomeres in embryos. Cyclin B1 protein and mRNA, whose translation is regulated by polyadenylation, are colocalized with CPEB and maskin. CPEB interacts w...

Journal: :Developmental cell 2014
Zhaoqing Wang Ming Fan Demet Candas Tie-Qiao Zhang Lili Qin Angela Eldridge Sebastian Wachsmann-Hogiu Kazi M Ahmed Brett A Chromy Danupon Nantajit Nadire Duru Fuchu He Min Chen Toren Finkel Lee S Weinstein Jian Jian Li

A substantial amount of mitochondrial energy is required for cell-cycle progression. The mechanisms underlying the coordination of the mitochondrial respiration with cell-cycle progression, especially the G2/M transition, remain to be elucidated. Here, we show that a fraction of cyclin B1/Cdk1 proteins localizes to the matrix of mitochondria and phosphorylates a cluster of mitochondrial protein...

2017
Teng Zhang Yang Zhou Li Li Zhen-Bo Wang Wei Shen Heide Schatten Qing-Yuan Sun

Meiotic resumption (G2/M transition) and progression through meiosis I (MI) are two key stages for producing fertilization-competent eggs. Here, we report that CenpH, a component of the kinetochore inner plate, is responsible for G2/M transition in meiotic mouse oocytes. Depletion of CenpH by morpholino injection decreased cyclin B1 levels, resulting in attenuation of maturation-promoting facto...

2016
WUJIE LI QING DONG LEI LI ZHENLEI ZHANG XIAOLAN CAI XINLIANG PAN

Claudin-l and cyclin B1 are abnormally expressed in certain malignancies, but their expression in hypopharyngeal squamous cell carcinoma (HSCC) has not been reported thus far. Studying the expression levels of claudin-1 and cylin B1 in HSCC tissues and their association with clinical stage, pathological grade and prognosis in patients with HSCC may provide a theoretical basis and guide future r...

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