Although cortisone acetate is approved worldwide as corticosteroid substitution therapy in congenital adrenal hyperplasia (21-hydroxylase deficiency), its effectiveness is uncertain since its biologic activity depends on activation by 11β-hydroxysteroid dehydrogenase (11β-HSD). We sought to compare the effect of cortisone acetate with that of hydrocortisone. In 10 patients with congenital adren...

In an earlier paper we described studies on the physiological disposition and metabolic fate of hydrocortisone in man (1). This paper describes similar studies on cortisone. Although contributing very little to the body pool of adrenal cortical steroids, cortisone has been used extensively as a therapeutic agent, and it was therefore of interest to compare its metabolism with that of hydrocorti...

Neovascular glaucoma is a challenging disease in its pathogenesis and treatment. Ischemic retinopathies can lead to neovascular glaucoma due to newly formed vessels on the iris surface and anterior chamber angle. Eyes with neovascular glaucoma can exhibit high intraocular pressure, usually treated by retinal coagulation, cyclodestructive procedures, or drainage procedures. Based on experimental...

In 1953 it was demonstrated by EngelbrethHolm and Asboe-Hansen (3) that intraperitoneal injection of cortisone markedly inhibits the devel opment of skin tumors and prolongs the latent period in ST/Eh mice painted once on the dorsum with 9,10-dimethyl-l,2-benzanthracene. In further experiments by Zachariae and AsboeHansen (4), hydrocortisone (17-hydroxycorticosterone) acetate, injected topicall...

Background Limited data are available on the efficacy of cortisone injections for glenohumeral osteoarthritis (GHOA). The amount and longevity pain relief provided by a single injection unclear. Additionally, it remains uncertain how severity radiographic GHOA patient-reported function levels impact an injection. Therefore, we sought to describe single, image-guided in patients with GHOA. We hy...

Measurement of increased latenight salivary cortisol (LNSC) is now a mainstay in the diagnosis of endogenous Cushing syndrome (1 ). Patients typically sample their saliva at home and are carefully instructed to avoid using potential contaminants, such as topical creams or ointments containing hydrocortisone (authentic cortisol). Using these creams or ointments can cause preanalytical contaminat...