conclusions we found a relatively high value of tc and tg in our study. considering the relationship between high levels of lipids in the neonatal period and coronary artery disease in the adult population, we recommend future cohort studies for this statistical society. results of the 174 neonates, 97 were female. vaginal delivery was recorded in 79.8%. there were no significant differences re...

Cord blood is a sample of blood taken from a newborn baby's umbilical cord.Cord blood is collected because it is rich in stem cells content, such as hematopoietic cells, which can be used to treat hematopoietic and genetic disorders. Cord Blood Transplantation has been used in the treatment of over 80 diseases, including leukemia, lymphoma and anemia. Advantages of Cord Blood Treatment: • ...

BACKGROUND B cells play an important role in the immune system due to production of the immunoglobulin and secreting several cytokines. It has been shown that B cells produced successfully in the presence of stem cell factor (SCF) and Flt3 ligand (Flt3L). IL2, IL7, and IL15 cytokines as the γc-common family have an essential role in lymphopoiesis. Common γ chain cytokines may support either syn...

stem cells are naïve or master cells. this means they can transform into special 200 cell types as needed by body, and each of these cells has just one function. stem cells are found in many parts of the human body, although some sources have richer concentrations than others. some excellent sources of stem cells, such as bone marrow, peripheral blood, cord blood, other tissue stem cells and hu...

Cord blood (CB) cells that express CD34 have extensive hematopoietic capacity and rapidly divide ex vivo in the presence of cytokine combinations; however, many of these CB CD34+ cells lose their marrow-repopulating potential. To overcome this decline in function, we treated dividing CB CD34+ cells ex vivo with several histone deacetylase inhibitors (HDACIs). Treatment of CB CD34+ cells with th...

A 33-year-old woman underwent unrelated cord blood transplantation (U-CBT) for myelodysplastic syndrome (MDS)-related secondary AML. She showed impressive increases in the number of CD19+ B cells in bone marrow and CD19+27-IgD+ B cells in peripheral blood from about 1 month to 3 months after U-CBT. The serum level of IL-6 temporarily increased after transplantation, and this increase seemed to ...

A recent Science paper reported a purine derivative that expands human cord blood hematopoietic stem cells in culture (Boitano et al., 2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome before ex vivo HSC expansion can be used clinically.

PURPOSE OF REVIEW To review the available clinical and biological advances of umbilical cord blood allogeneic stem cell transplantation in pediatric and adult patients. RECENT FINDINGS Recent large international studies suggested that allogeneic umbilical cord blood transplantation may potentially emerge as the frontline stem cell source for pediatric patients with hematopoietic malignancies ...