background: valproic acid (vpa) is an effective antiepileptic drug widely used worldwide. despite several studies indicating the usefulness of intravenous l-carnitine in the treatment of vpa poisoning, this drug is not readily available in iran. the aim of this study was to determine whether supportive care without antidote would result in acceptable outcomes in vpa poisoned patients. materials...

traffic accident has increased in the last decade. one of the most important outcomes of accident is spinal cord injury (sci). so, cell therapy is obtained a greater attention in most fields of medicine because of its potential for incurable diseases through replacing of dead cells. the current study aims to describe the important of locomotor functional and structural connection of the spinal ...

background valproic acid is widely used as an anticonvulsant and mood-stabilizing drug in the treatment of epilepsy. determination of serum valproic acid is required in epilepsy therapy for efficient control of seizures. objectives in the present study, the gas chromatography method was applied to determine serum valproic acid and resulting data were compared with those obtained by high perform...

Valproic acid is widely used in the treatment of many diseases. It has common side effects such as nausea, vomiting, diarrhea, dizziness, tremor, hair loss, thrombocytopenia. can rarely cause eosinophilic pleuropericardial effusion. Case report; a 31-year-old male patient who had been using valproic since childhood due to epilepsy presented with respiratory distress. Eosinophilic effusion was d...

The complex [PtCl 2 (cyclohexane-1 R ,2 -diamine)] has been combined in a Pt(IV) molecule with two different bioactive molecules (i.e., the histone deacetylase inhibitor 2-propylpentanoic acid or valproic acid, VPA , and potential antimetastatic...

A bioanalytical HPLC method with UV detection for the determination of the antiepileptic drug valproic acid in human saliva has been developed and validated. Saliva represents an alternative matrix for therapeutic monitoring of antiepileptic drugs due to the increasing interest in free drug concentration. The proposed method involved solid-phase extraction for sample preparation and yielded ver...

We report a case of a patient who had been on long time valproic acid for treatment of bipolar affective disorder. While being an inpatient, serology ammonia level testing revealed a very high ammonia level despite being asymptomatic. Dual therapy of carnitine and lactulose was provided to the patient for treatment of the hyperammonemia. It should also be noted that, during this treatment, valp...

Valproic acid is an effective, frequently used anticonvulsant drug. Typical adverse effects include weight gain, hair loss, and nausea. Hyperpigmentation, onycholysis, and onychomadesis are nail changes that can be seen after valproic acid use. Changes occur at the distal and proximal portions of the nail bed in onycholysis and onychomadesis, respectively. Onychomadesis is a very rare disease o...

Introduction Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity. The aim of this study was to investigate valproic acid impact on liver transaminases at the beginning of VPA treatment and after three and six months of it. Materials and Methods This study was designed as a cross sectional pro...

BACKGROUND Different types of medications are currently used in vestibular migraine (VM) prophylaxis, although recommendations for use are generally based on expert opinion rather than on solid data from randomized trials. We evaluated the efficacy and safety of venlafaxine, flunarizine, and valproic acid in a randomized comparison trial for VM prophylaxis. METHODS Subjects were randomly allo...