Colorectal Cancers (CRC) are one of the top ten cancers to increase burden on health care system in India. Often patients experience symptoms after carcinoma has significantly progressed. Timely and accurate screening target population remains a challenge for clinicians.

Colorectal mucosa from patients with colorectal carcinoma was compared with rectal mucosa from a control group. It was found that the LDH isoenzyme pattern of uninvolved mucosa proximal and distal to the carcinoma differed from that of normal tissue and resembled that of carcinoma tissue except in the case of the uninvolved mucosa proximal to the carcinoma of the sigmoid colon, which did not di...

Thymidine phosphorylase (TP) is a key enzyme that contributes to the composition and decomposition of pyrimidine nucleotides. TP seems homologous to platelet-derived endothelial cell growth factor, and its effects on inducing vascularization and anti-apoptosis are closely related to growth and metastasis of colorectal carcinoma. In addition, TP is a key enzyme that catalyzes the transformation ...

BACKGROUND Plasma interleukin-6 (IL-6) level correlates with patient survival in colorectal carcinoma and is regarded as a prognostic factor. In this study, the role of IL-6 in colorectal carcinoma proliferation, chemotaxis and invasion was investigated. MATERIALS AND METHODS Proliferation and invasion were measured in four colorectal carcinoma cell lines. The effect of IL-6 (10, 50, 100 ng/m...

Teng-Long-Bu-Zhong-Tang (TLBZT) is a Chinese herbal formula for colorectal carcinoma treatment. TLBZT effectively induces cell senescence in colorectal carcinoma, accompanied by p21 upregulation. In this study, we further explored the role of p21 in TLBZT-induced cell senescence, as well as the mechanism by which TLBZT upregulates p21. Specific knockdown of p21 expression by small interfering R...

BACKGROUND Evidence indicates that most cases of colorectal carcinoma (CRC) develop from adenoma. A previous study demonstrated that mitochondrial Tu translation elongation factor (TUFM) might serve as an independent prognostic factor for colorectal cancer. However, the expression and function of TUFM in the normal-adenoma-cancer sequence have not been reported. In this study, we investigated t...

BACKGROUND MUC5AC is a secreted mucin aberrantly expressed by colorectal polyps and carcinoma. It has been hypothesized that aberrant expression of MUC5AC in colorectal carcinoma tissues increased the overall survival of patients with colorectal carcinoma. The present study investigates the incidence of naturally occurring MUC5AC antibodies in the sera of normal individuals, patients with colon...

Background & Objective: The current approaches to reduce the risk of colorectal carcinoma are through the detection and removal of the precursor lesion” adenomatous polyps”. The study was conducted to evaluate the immunohistochemical expression of p53 and bcl-2 in colorectal adenomas and carcinomas. Patients and Methods: A total of 86 cases, 33 colorectal adenomas, 33 colorectal adenocarcinomas...

Purpose Diagnosis of colorectal carcinoma on contrast-enhanced CT relies on demonstration of rectosigmoid wall thickening, perirectal fat stranding, and perirectal lymph nodes. Wall thickening may be the only sign in early carcinoma, and may be mimicked by spasm or adherent faecal matter. Rectosigmoid carcinoma may result in earlier venous return in inferior mesenteric vein (IMV) compared to su...