how to cite this article: aghayan golkashani h, hatami h, farzan a, mohammadi hr, nilipour y, khoddami m, jadali f. tumors of the central nervous system: an 18-year retrospective review in a tertiary pediatric referral center. iran j child neurol. summer 2015;9(3):24-33.   abstract objective few studies exist on the demographics and trends of pediatric central nervous system (cns) tumors in ira...

AIM The purpose of the present study was to compare microarray gene-expression profiling data between primary central nervous system (CNS) lymphoma and non-CNS lymphomas. MATERIALS AND METHODS We performed whole-genomic cDNA-mediated annealing, selection and ligation assay with 177 formalin-fixed paraffin-embedded tumor samples. RESULTS We identified 20 differentially expressed genes out of...

Medulloepithelioma is a rare embryonal tumor of the central nervous system (CNS). Its distinct appearance is characterized by papillary and tubular arrangements of malignant singleto multi-layered columnar epithelium surrounded by an outer basement membrane. For years, this tumor has been viewed as an embryonal tumor that recapitulates the earliest stage of CNS development, namely the neural tu...

Abstract BACKGROUND Effective immunotherapy against tumors of the central nervous system (CNS) requires that drug blood brain barrier (BBB) and encounter immune cells. We have previously described a mechanism which may facilitate transport CD3-engaging therapeutics into CNS, via carriage on activated T Building this, we sought to produce specific cell phenotypes rapidly enter accumulate in CNS....

background: central nervous system (cns) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, intrathecal chemotherapy and cranial irradiation. the purpose of this study was to compare the effectiveness of intrathecal (it) cns chemotherapy alone versus combination of it chemotherapy with cranial irradiation for prevention of cns rel...

Cancer immunotherapy is the use of the immune system to reject cancers. The main premise is to harness the patient's immune system to attack the malignant tumor cells. This area of research has made tremendous progresses, and the United States Food and Drug Administration recently approved a vaccine for prostate cancers as the first approval for vaccines against non-viral cancers (Kantoff et al...

Central neurocytoma (CN) is a rare, benign brain tumor often located in the lateral ventricles. CN may cause obstructive hydrocephalus and manifest as signs of increased intracranial pressure. The goal of treatment for CN is a gross total resection (GTR), which often yields excellent prognosis with a very high rate of tumor control and survival. Adjuvant radiosurgery and radiotherapy may be con...

BACKGROUND The incidence of primary central nervous system (CNS) melanocytic neoplasms is relatively low comparing to systemic ones. The performance of the tumor is variable. With poor clinical experience, the diagnosis and treatment of such tumors present to be a challenge. Amelanotic melanoma is an especially rare subtype. Only several cases have been reported. CASE PRESENTATION We report a...

Inflammation is portion of the body's immune response and it is basically a host protective response to tissue ischemia, injury, autoimmune responses or infectious agents. Although the information presented so far points to a detrimental role for inflammation in central nervous system (CNS) disease, it may also be useful. CNS demonstrates characteristic of inflammation, and in response to damag...

Abstract Antibody-based conjugates (ADCs) have transformed the treatment of Her2+ breast and other cancers. Unfortunately, CNS remains a sanctuary site for many such patients in part due to differential activity macromolecules across blood-brain tumor barriers. Trastuzumab deruxtecan (T-DXd), high-payload ADC, was recently found improve progression-free survival cancer compared with prior-gener...