results the frequencies of the aa, at, and tt genotypes were 31%, 51%, and 18% in the chronic hbv patient group, and 40%, 45%, and 15% in the healthy control group, respectively. however, a lack of association of the + 874 polymorphism in the ifn-γ gene of those with chronic hbv infection was found. evaluation of hbv association with this polymorphism was significant under the dominant genetic ...

a hepatitis b virus (hbv) infection is a global public health problem. in endemic areas, hbv infection occurs mainly during infancy and early childhood, with mother to child transmission (mtct) accounting for approximately half of the transmission routes of chronic hbv infections. prevention of mtct is an essential step in reducing the global burden of chronic hbv. natal transmission accounts f...

The substantial global burden of hepatitis B virus (HBV) infection is increasingly recognised. Recent estimates suggest that HBV infection caused 686 000 deaths in 2013, placing HBV in the top 20 causes of human mortality. Despite this, comprehensive reviews of data regarding the burden of chronic HBV at regional and national levels have been scarce. This is an area of particular importance in ...

The aim of this study was to investigate the characteristics of serum secreted frizzled-related protein 5 (SFRP5), an inhibitor of Wnt signaling, in hepatitis B virus (HBV)-associated infections and hepatocellular carcinoma (HCC) patients. Serum SFRP5 levels were detected in 147 patients with HBV-associated chronic infection or HCC. Compared with the non-HBV-infected and non-HCC group, the HBV-...

Background an aims: Current interferon alfa (IFN) treatment of chronic hepatitis B has limited efficacy. The role of hepatitis B virus (HBV) genotypes for response to IFN was investigated. Patients and methods: HBV genotype was determined by direct sequencing of the HBV X gene in 165 consecutive patients with chronic replicative hepatitis B treated with standard IFN. HBV genotype A or D was fou...

Approximately 350 million people worldwide are living with chronic hepatitis B virus (HBV) infection, and an estimated 620,000 die annually from complications of HBV-related liver disease [1]. In the United States, the incidence of acute HBV infection has declined substantially since 1985 as a result of the availability of effective HBV vaccines and widespread immunization of infants and high-r...

BACKGROUND Sub-Saharan Africa carries a high burden of co-infection with HIV-1 and hepatitis B virus (HBV). In this region, individuals with HIV-1/HBV co-infection on antiretroviral therapy (ART) frequently receive lamivudine as the only agent active against HBV, raising concerns for development of HBV resistance to lamivudine. We aimed to determine the prevalence, clinical, and virologic outco...

OBJECTIVE To investigate the mechanism underlying the development of chronic hepatitis B virus infection (HBV) in Turkish population using HLA tissue typing. METHODS The study group I consisted of 20 patients with HBV-related chronic liver disease (cirrhosis, chronic active hepatitis or chronic persistent hepatitis). The study group II included 30 HBV chronic carriers. The control group consi...

The hepatitis B virus (HBV) carrier rate has decreased in Japan; however, the incidence of HBV infection among hepatocellular carcinoma (HCC) patients has not decreased accordingly. In this study, we aimed to assess the time trends of the clinical characteristics in HCC patients with chronic HBV infection. Between 2000 and 2012, we enrolled a total of 156 HCC patients with chronic HBV infection...

Hepatitis B virus (HBV) infection is a global public health problem. In endemic areas, HBV infection occurs mainly during infancy and early childhood, with mother to child transmission (MTCT) accounting for approximately half of the transmission routes of chronic HBV infections. Prevention of MTCT is an essential step in reducing the global burden of chronic HBV. Natal transmission accounts for...