نتایج جستجو برای: chop

تعداد نتایج: 4508  

Journal: :Infection and immunity 2007
Christopher J Kuckleburg Shaadi F Elswaifi Thomas J Inzana Charles J Czuprynski

Histophilus somni-induced platelet aggregation was inhibited by antagonists of the platelet-activating factor (PAF) receptor but not inhibitors of PAF synthesis. In addition, H. somni cells expressing phosphorylcholine (ChoP) induced aggregation, while ChoP(-) H. somni cells did not. This suggests that H. somni ChoP may induce platelet aggregation via interactions with the PAF receptor.

2012
HONG-HUI HUANG FEI XIAO FANG-YUAN CHEN TING WANG JUN-MIN LI JIAN-MIN WANG JUN-NING CAO CHUN WANG SHAN-HUA ZOU

The International Prognostic Index (IPI) is a widely accepted model that is used to predict the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) who are treated using chemotherapy. However, the prognostic value of the IPI has been a focal point of debate in the immunochemotherapy era. The aim of this study was to reassess the value of the IPI and revised IPI (R-IPI) in a Chinese...

2015
Gagandip K. Poone Henrik Hasseldam Nina Munkholm Rune S. Rasmussen Nina V. Grønberg Flemming F. Johansen Bruno Meloni

Hypoxia induced endoplasmic reticulum stress causes accumulation of unfolded proteins in the endoplasmic reticulum and activates the unfolded protein response, resulting in apoptosis through CCAAT-enhancer-binding protein homologous protein (CHOP) activation. In an in vitro and in vivo model of ischemic stroke, we investigated whether hypothermia regulates the unfolded protein response of CHOP ...

2017
Kequan Chen Yang Pang Bowen Zhang Jiao Feng Sheng Xu Xin Wang Pingkai Ouyang

BACKGROUND Understanding the bioprocess limitations is critical for the efficient design of biocatalysts to facilitate process feasibility and improve process economics. In this study, a proline hydroxylation process with recombinant Escherichia coli expressing L-proline cis-4-hydroxylase (SmP4H) was investigated. The factors that influencing the metabolism of microbial hosts and process econom...

Journal: :Journal of medical economics 2014
Gregory Hill Richard Barron Kelly Fust Michelle E Skornicki Douglas C A Taylor Milton C Weinstein Gary H Lyman

OBJECTIVE Evaluate the cost-effectiveness of primary vs secondary prophylaxis (PP vs SP) with pegfilgrastim to reduce the risk of febrile neutropenia (FN) in Non-Hodgkin's Lymphoma (NHL) patients receiving myelosuppressive chemotherapy from a US payer perspective. METHODS A Markov model was used to compare PP vs SP with pegfilgrastim in a cohort of patients receiving six cycles of cyclophosph...

Journal: :Blood 2001
M Leporrier S Chevret B Cazin N Boudjerra P Feugier B Desablens M J Rapp J Jaubert C Autrand M Divine B Dreyfus K Maloum P Travade G Dighiero J L Binet C Chastang

To comparatively assess first-line treatment with fludarabine and 2 anthracycline-containing regimens, namely CAP (cyclophosphamide, doxorubicin plus prednisone) and ChOP (cyclophosphamide, vincristine, prednisone plus doxorubicin), in advanced stages of chronic lymphocytic leukemia (CLL), previously untreated patients with stage B or C CLL were randomly allocated to receive 6 monthly courses o...

Journal: :International journal of oncology 2011
Shota Moriya Keisuke Miyazawa Tomohiro Kawaguchi Xiao-Fang Che Akio Tomoda

In this study, 2-aminophenoxazine-3-one (Phx-3) exhibited a potent cell growth inhibitory effect with apoptotic features in a dose-dependent manner in various cancer cell lines tested. Comparison of the expression profiles of endoplasmic reticulum (ER) stress-related genes in U266 multiple myeloma cells after treatment with Phx-3 and the ER stress inducers tunicamycin (TNM) and thapsigargin (TP...

2012
Shaadi F Elswaifi William K Scarratt Thomas J Inzana

Histophilus somni is a Gram-negative bacterium and member of the Pasteurellaceae that is responsible for respiratory disease and other systemic infections in cattle. One of the bacterium's virulence factors is antigenic phase variation of its lipooligosaccharide (LOS). LOS antigenic variation may occur through variation in composition or structure of glycoses or their substitutions, such as pho...

2009
Jenna L. Yoder Khalid M. Kamal

Objectives: To explore the use of pharmacoeconomic principles through examination of economic evaluations pertaining to the combination of the monoclonal antibody rituximab with conventional CHOP (cyclophosphamide/doxorubicin/ vincristine/prednisone) or CHOP-like chemotherapy regimens in patients with non-Hodgkin lymphoma. Methods: A literature search was conducted using Evidence-Based Medical ...

Journal: :Blood 2003
Herve Tilly Eric Lepage Bertrand Coiffier Michel Blanc Raoul Herbrecht Andre Bosly Michel Attal Georges Fillet Catherine Guettier Thierry Jo Molina Christian Gisselbrecht Felix Reyes

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least on...

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