Chemical genetics is the study of biological systems using small molecule ('chemical') intervention, instead of only genetic intervention. Cell-permeable and selective small molecules can be used to perturb protein function rapidly, reversibly and conditionally with temporal and quantitative control in any biological system. This tutorial review has been written to introduce this emerging field...

Extensive modelling studies on nitrogen (N) dynamics in flooded soil systems have been published. Consequently, many N dynamics models are available for users to select from. With the current research trend, inclined towards multidisciplinary research, and with substantial progress in understanding of N dynamics in flooded soil systems, the objective of this paper is to provide an overview of t...

Background: Chronic sleep deprivation through activation of sympathetic nervous system leads to destructive effect on different body organs. We assessed the effect of chronic sleep deprivation on incidence of ischemia/reperfusion-induced ventricular arrhythmias (ventricular tachycardia and ventricular fibrillation) and the role of the sympathetic nervous system in this respect. Materials and Me...

The undamaged test of a range of aplousobranch ascidian species is shown to be chemically neutral. Acid is generated by surface test cells following cell lysis and is rapidly neutralised in the presence of calcareous test inclusions and/or sea water. Neither the capacity to produce acid nor the presence of vanadium prevents predation on ascidian species in the field.

X iv :a st ro -p h/ 04 05 00 9v 1 1 M ay 2 00 4 The Chemical Properties of Milky Way and Andromeda Globular Clusters: I. A Comparative Study Michael A. Beasley Lick Observatory, University of California, Santa Cruz, CA 95064, USA [email protected] Jean P. Brodie Lick Observatory, University of California, Santa Cruz, CA 95064, USA [email protected] Jay Strader Lick Observatory, University o...

Transcoronary chemical ablation of ventricular tachycardia was recently performed in one patient with refractory ventricular tachycardia in our hospital. The procedure was successful. The arrhythmia was cured and no recurrence occurred in a 24-month period. The clinical application and mechanism of transcoronary chemical ablation were discussed.

Oxidized methionine residues in peptide thioesters can be reduced rapidly with NH4I to the corresponding sulfide by using Me2S as coreductant. Comparative reduction studies employing a 28-amino acid peptide thioester with an N-terminal methionine oxide as model system revealed the importance of the Me2S addition to avoid hydrolysis of the reactive thioester functionality. In addition, an NH4I-M...

:omposition but to zero change at the ,eak. I would point out to Andrews that ialid conclusions cannot be drawn from -alculations which fail to take precipi.ation into account. The isotopic evidence demonstrates :hat there was a massive flood in the Gulf )f Mexico, peaking about 11,600 years igo. Since nature is self-consistent, I ;uggest that those who have commented n our report revisit their...