A 69-year-old man presented to an outside hospital with fatigue, fevers, altered mental status, and dyspnea. Laboratory testing revealed a white blood cell count of 231 × 103/μL with 88% blasts, hemoglobin of 6.2 g/dL, and platelet count of 80 × 103/μL. Bone marrow biopsy confirmed a diagnosis of acute myeloid leukemia (AML) with flow cytometric analysis demonstrating two abnormal myeloblast po...

A growing body of studies highlights involvement of neutrophils in cancer development and progression. Our aim was to assess the phenotypic and functional properties of circulating neutrophils from patients with chronic lymphocytic leukemia (CLL). The percentage of CD54+ and CD64+ neutrophils as well as CD54 expression on these cells were higher in CLL patients than in age-matched healthy contr...

Article history: Received on: 14/12/2014 Revised on: 08/01/2015 Accepted on: 22/01/2015 Available online: 27/02/2015 Testis is the tissue with immune privilege which is maintained by blood-testis barrier to protect autoimmunogenic components of testis. IgG have binding affinity for CD16, CD32 and CD64 receptors present on various immune cells. Present study was conducted to investigate the IgG ...

BACKGROUND/AIMS Microglia are the primary antigen presenting cells in the central nervous system and the retina, and can harbour viral antigens that may damage neural tissue via the release of neurotoxins. All cells bearing CD4 molecules and co-receptors (members of the chemokine receptor and Fcgamma receptor families) are potential targets for the human immunodeficiency virus (HIV). In this st...

To date, no curative therapy is available for the treatment of most chronic inflammatory diseases such as atopic dermatitis, rheumatoid arthritis, or autoimmune disorders. Current treatments require a lifetime supply for patients to alleviate clinical symptoms and are unable to stop the course of disease. In contrast, a new series of immunotherapeutic agents targeting the Fc γ receptor I (CD64)...

Background/aims: Microglia are the primary antigen presenting cells in the central nervous system and the retina, and can harbour viral antigens that may damage neural tissue via the release of neurotoxins. All cells bearing CD4 molecules and co-receptors (members of the chemokine receptor and Fcc receptor families) are potential targets for the human immunodeficiency virus (HIV). In this study...

Current systems for conditional gene deletion within mouse macrophage lineages are limited by ectopic activity or low efficiency. In this study, we generated a Mafb-driven Cre strain to determine whether any dendritic cells (DCs) identified by Zbtb46-GFP expression originate from a Mafb-expressing population. Lineage tracing distinguished macrophages from classical DCs, neutrophils, and B cells...

Abstract Background The aim of the study was to conduct a meta-analysis evaluate accuracy neutrophil CD64, procalcitonin (PCT), and interleukin-6 (IL-6) as markers for diagnosis sepsis in adult patients. Methods Various databases were searched collect published studies on patients using PCT, IL-6 levels. Utilizing Stata SE 15.0 software, forest plots area under summary receiver operating charac...