Abstract Background Local sequence context is known to have an impact on the mutational pattern seen in cancer. The RAS genes and a smoking carcinogen, Benzo[a]pyrene diol epoxide (BPDE), been utilised explore these effects. BPDE form adduct at guanines number of gene sites, KRAS codons 12, 13 14, NRAS codon HRAS 12 14. Results Molecular modelling techniques, along with multivariate analysis, d...

Parthenolide is a secondary metabolite, which naturally occurs in the feverfew plant and is responsible for its healing power. The potential of parthenolide in inhibition of cancer cell growth, alone or in combination with other anti-cancer therapeutics, have been studied in several laboratories. In this study, the effect of extracted parthenolide on the expression of seven pro-apoptotic genes,...

The identification of genes causing a genetic disease is still an important issue in the biomedical field because list incomplete while it determines early diagnosis and treatment fatal diseases such as autism, cancer, drug resistance, secondary hypertension. Genes associated with particular or similar tend to reside same region biological network their location on can be predicted. Many analys...

Breast cancer can be caused by germline mutations in several genes that are responsible for different hereditary cancer syndromes. Some of the genes causing the Fanconi anemia (FA) syndrome, such as BRCA2, BRIP1, PALB2, and RAD51C, are associated with high or moderate risk of developing breast cancer. Very recently, SLX4 has been established as a new FA gene raising the question of its implicat...

Esophageal cancer (EC) is the sixth main cause of cancer death worldwide. Important genes associated with esophageal cancer include FOXO3, AKT, and GSK3β. Excessive FOXO3 expression inhibits the proliferation of cancer cells. The expression of AKT is involved in controlling cell growth in tumors. GSK3β activity is higher in cancer tissues. Given the effective role of cancer stem cells (CSCs) in...

background and aims: recently it has been proved that some of enterobacteriacea like klebsiella pneumoniae, which carry pks islands, damage dsdna by encoding colibactin genotoxin; and finally they induce some apoptosis in damaged mucosal cells. this study aimed to isolating the clbn and clbb genes, which are the markers of the pks genomic island, from pks cluster in these bacteria materials and...

gastric cancer (gc) is the second most common cancer in the world and a leading cause of cancer-related mortality. methylation of promoter cpg islands (cgis) belonging to tumor suppressor genes causes transcriptional silencing of their corresponding genes leading to carcinogenesis and other disorders. adenomatous polyposis coli (apc) a tumor suppressor gene is inactivated by methylation of prom...