Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome Carlo Pappone, MD, PhD; Josep Brugada, MD, PhD; Gabriele Vicedomini, MD; Giuseppe Ciconte, MD; Francesco Manguso, MD, PhD; Massimo Saviano, MD; Raffaele Vitale, MD; Amarild Cuko, MD; Luigi Giannelli, MD; Zarko Calovic, MD; Manuel Conti, MD; Paolo Pozzi, Eng; Andrea Natalizia, PhD, Eng; Simonetta Crisà, Eng; Valer...

PURPOSE OF REVIEW The Brugada syndrome has been an area of intensive investigation since its earliest description in 1992, both on a clinical and on a basic research level. In this review, we will focus on recent achievements in the molecular dissection of the disease pathophysiology and on large multicenter studies dealing with prognostic markers and the natural history of the Brugada syndrome...

Introduction. Brugada syndrome accounts for about 4% of sudden cardiac deaths (SCD). It is characterized by an ST-segment elevation in the right precordial electrocardiogram (EKG) leads. Case Presentation. We describe a 39-year-old healthy Caucasian man who was admitted to the intensive care unit after being cardioverted from ventricular fibrillation (VF) arrest. His past history was significan...

Background. Brugada syndrome is rare and has been a clinically diagnosable entity since 1992. Its clinical manifestations are highly variable, and while some patients remain asymptomatic, others endure sudden cardiac death. Initial presenting symptoms may include palpitations, seizures, syncope, and nocturnal agonal respiration. The diagnosis of Brugada syndrome relies on both clinical findings...

The authors report the first catheter ablation of Brugada syndrome in the literature using the Rhythmia™ mapping system. Learning points include: (1) low voltage areas can be documented while mapping in some individuals, suggesting that Brugada syndrome may not be a pure ion channel disorder; (2) typical long fractionated potentials can also be identified in the endocardium, supporting the need...

Brugada syndrome is a congenital electrical disorder characterised by the appearance of distinctive QRST-T patterns in the right precordial leads and an increased risk of sudden death (SCD) in young healthy adults. Although chamber enlargement is not apparent in most cases, autopsy and histological investigations have revealed structural abnormalities. The typical Brugada ECG manifestation is o...

genetic basis of diffrent arrhythmias has always been an intresting subject of resesrch for scientists. here i will review in brief the most common familia arrhythmias and the new findings regarding their mode of inhetitance. this paper will mainly focus on the genetic basis of the long qt syndromes but we will also have a short review of the genetics of three other familia congenital arrhythmo...

Introduction Brugada syndrome is known to be a life-threatening disease provoking lethal arrhythmias such as ventricular tachycardia/ventricular fibrillation (VF), but non–implantable cardioverter-defibrillator (ICD) treatment strategy remains a topic of discussion. Substrate-based catheter ablation of Brugada syndrome has been reported to be effective, but much is still unknown, for example, t...

BACKGROUND Patients with Brugada syndrome present with characteristic ECG abnormalities (atypical right bundle-branch block and ST-segment elevation) and life-threatening ventricular tachyarrhythmias despite structurally normal hearts. Involvement of the autonomic nervous system is suggested by the occurrence of ventricular tachyarrhythmias and sudden death at rest or during sleep and by change...