Studying different concepts by frequently alternating between them (i.e., interleaving), improves discriminative contrast between different categories, while studying each concept in separate blocks emphasizes the similarities within each category. Interleaved study has been shown to improve learning of high similarity categories by increasing between-category comparison, while blocked study im...

A new approach, graph-grammars, to encode RNA tertiary structure patterns is introduced and exemplified with the classical sarcin-ricin motif. The sarcin-ricin motif is found in the stem of the crucial ribosomal loop E (also referred to as the sarcin-ricin loop), which is sensitive to the alpha-sarcin and ricin toxins. Here, we generate a graph-grammar for the sarcin-ricin motif and apply it to...

Ricin is a type II ribosome-inactivating protein (RIP) that depurinates A4324 at the sarcin-ricin loop of 28 S ribosomal RNA (rRNA), thus inactivating the ribosome by preventing elongation factors from binding to the GTPase activation centre. Recent studies have disclosed that the conserved C-terminal domain (CTD) of eukaryotic ribosomal P stalk proteins is involved in the process that RIPs tar...

Ključne riječi: osteoartritis, patofiziologija, sinovitis, hrskavica, starenje, mehanički stres Sažetak Osteoartritis je poremećaj na razini organa. Zahvaća sve strukture zgloba. Biomehanički i genetski čimbenici igraju važnu ulogu u nastanku i napredovanju osteoartritisa, dok je upala važna u progresiji bolesti i degradaciji hrskavice uzrokujući bol, oteklinu i zakočenost zgloba. Novije spozna...