2 Introduction Within the Principle and Parameters model of Universal Grammar (UG), double negatives, which I will henceforth refer to as Negative Concord (NC), have been argued to invoke a fundamental syntactic relation between the head and the specifier of a constituent. More precisely, it has been proposed that sentential negation universally projects a syntactic constituent conform to X' th...

Even in a safe programming language, such as C or Java, disobeying the rules for using an interface can cause exceptions at run time. Such rules govern how system resources are managed, the order of method calls, and the formatting of string parameters, such as SQL queries. This paper introduces Fugue, a modular static checker for languages that compile to the Common Language Runtime. Fugue all...

INTRODUCTION The aim of the present study was to screen for bipolarity and to investigate the affective temperaments of patients with multiple sclerosis (MS) and the possible association between the clinical and demographic characteristics of MS patients and temperament profiles. METHODS A total of 65 patients with MS and 66 healthy volunteers completed the 32-item hypomania checklist (HCl-32...

Accurate chromosome segregation relies on the bipolar mitotic spindle. In many eukaryotes, spindle formation is driven by the plus-end-directed motor kinesin-5 that generates outward force to establish spindle bipolarity. Its inhibition leads to the emergence of monopolar spindles with mitotic arrest. Intriguingly, simultaneous inactivation of the minus-end-directed motor kinesin-14 restores sp...

OBJECTIVE Features of bipolarity in a major depressive disorder sample were used to define a "bipolar spectrum disorder" population for treatment with a neuroleptic agent, ziprasidone. METHODS Forty-nine acutely depressed patients were randomized to ziprasidone-washout-placebo or placebo-washout-ziprasidone in this double-blind, prospective, 13-week crossover trial. All patients met the Diagn...

Although recently more research has considered children with bipolar disorder than in the past, much controversy still surrounds the validity of the diagnosis. Furthermore, questions remain as to whether or not childhood expressions of bipolarity are continuous with adult manifestations of the illness. In order to advance current knowledge of bipolar disorders in children, researchers have begu...