kaolin-so3h as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. this natural based catalyst is very inexpensive and easy available. imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, anti...

Cathepsin K and S are two isoforms of cysteine protease with diverse biological functions in the aspect osteoporosis autoimmune diseases. Accordingly, homologous sequence similar binding site features among CTSK/S may lead to unselective inhibition side effects. To address such issue, various computational strategies were applied current study explore selectivity mechanism inhibitors, including...

Cancer is one of the most common diseases in world. Th e transcription factor NF-κB plays a key role various physiological processes including immune response, cell proliferation, apoptosis and inflammation. Due to participation NF-kappa B signaling pathways carcinogenesis, angiogenesis, tumor resistance chemo- radiotherapy, considered be ideal target for pharmacological treatment cancer. paper...

the impact of three different fabaceous host plants including cowpea (vigna unguiculata), chickpea (cicer arietinum), and mung bean (vigna radiata) seeds was investigated using biochemical approaches on possible changes of gut proteolytic activity of the cowpea weevil, callosobruchus maculatus at 30±1˚c and 70±5% rh and a photoperiod of 8:16 (l:d). results revealed that ph of 4-5 and 9 was opti...

Sirtuins regulate a variety of biological pathways and inhibitors of sirtuins have been actively pursued as tool compounds to study sirtuin biology and as potential therapeutics. Here we demonstrate that thiomyristoyl peptides are potent and cell-permeable inhibitors of Sirt6, one of the seven human sirtuins, and will serve as the starting point for the development of more specific Sirt6 inhibi...

Proteolytic enzymes are ubiquitous in all organisms and constitute 2–4% of encoded gene products. They are critical for diverse biological processes such as digestion, blood clotting, host defense, pathogenic infection, viral replication, wound healing, and disease progression, to name but a few. Because proteases trigger an irreversible event—the cleavage of a protein—their activity must be ti...

Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary cells. Identification of the inhibitors was...

To protect materials against biodeterioration, physical, biological or chemical methods can be used. Chemical inhibitors of biodeterioration are the most common and effective. A new class of chemical inhibitors-gemini alkylammonium salts-shows excellent biocidal properties and good ecological profile. These compounds can be applied as biodeterioration inhibitors in a wide variety of materials.