نتایج جستجو برای: biological inhibitors

تعداد نتایج: 638840  

To assess the effect of micro-organisms on the reduction of wax appearance temperature (WAT) of waxy crude oil, some appropriate strains were obtained from contaminated samples exposed to hydrocarbon compounds for a long time. By conducting some screening tests, four strains were chosen and aerated in a bioreactor; they were then grown in some hydrocarbon environments in order to produce biolog...

Introduction: Protein kinase causes many diseases, including cancer; therefore, inhibiting them plays an important role in the treatment of many diseases. Traditional discovery inhibitors of this enzyme is a time-consuming and costly process. Finding a reliable computer-aided drug discovery tools which can detect the inhibitors will reduce the cost. In this study, it is attempted to separate ki...

Introduction: Protein kinase causes many diseases, including cancer; therefore, inhibiting them plays an important role in the treatment of many diseases. Traditional discovery inhibitors of this enzyme is a time-consuming and costly process. Finding a reliable computer-aided drug discovery tools which can detect the inhibitors will reduce the cost. In this study, it is attempted to separate ki...

Journal: :research in pharmaceutical sciences 0

a quantitative structure–activity relationship (qsar) study is suggested for the prediction of biological activity (pic 50 ) of 3, 4-dihydropyrido [3 ,2-d] pyrimidone derivatives as p38 inhibitors. modeling of the biological activities of compounds of interest as a function of molecular structures was established by means of principal component analysis (pca) and least square support vector mac...

Journal: :Acta Veterinaria Scandinavica 1971

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

Journal: :the iranian journal of pharmaceutical research 0
jamal shamsara pharmaceutical research center, school of pharmacy, mashhad university of medical sciences, iran ahamad shahir-sadr bioinformatics research center, sabzevar university of medical sciences, school of medicine, sabzevar, iran.

design of selective cyclooxygenase-2 (cox-2) inhibitors is still a challenging task because of active site similarities between cox isoenzymes. to help with this issue, we tried to generate a 3d-qsar (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of cox-2 active sites. compounds in a series of resveratrol derivatives inhibitors with ...

Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...

Journal: :Bioresource technology 2013
Guangli Cao Eduardo Ximenes Nancy N Nichols Leyu Zhang Michael Ladisch

Removal of enzyme inhibitors released during lignocellulose pretreatment is essential for economically feasible biofuel production. We tested bio-abatement to mitigate enzyme inhibitor effects observed in corn stover liquors after pretreatment with either dilute acid or liquid hot water at 10% (w/v) solids. Bio-abatement of liquors was followed by enzymatic hydrolysis of cellulose. To distingui...

Abstract: Objective(s): In recent years, the chemistry of 2-chloroquinoline-3-carbaldehydes have received considerable attention owing to their synthetic and effective biological importance which exhibits a wide variety of biological activity, N1,N4-bis((2-chloroquinolin-3-yl)methylene)benzene-1,4-diamine derivatives that synthesized from 2-chloroquinoline-3-carbaldehydes may have biological ef...

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