Background. The mechanism of stroke in beta-thalassemia was reported previously as cardioembolic and hypercoagulable state. However, there is no report of watershed infarct in beta-thalassemia anemia. Method. We present an adult β-thalassemia major patient with manifest asymptomatic chronic left carotid occlusion who suffered watershed infarct. Result. In the presence of asymptomatic chronic le...

background : using two logistic regression models, we determined the associates of poor physical and mental health related quality of life (hrqol) among beta thalassemia patients. methods : in this cross-sectional study which was conducted during 2006 and 2007 in outpatient adult thalassemia clinic, blood transfusion organization, tehran, iran, short form 36 (sf-36) was used for measuring hrqol...

Thalassemia is the name of a group of genetic, inherited disorders of the blood. More specifically, it is a disorder of the hemoglobin molecule inside the red blood cells. According to World health Organization (WHO), there are about 3% beta-thalassemia carrier and about 4% Hb E/beta-thalassemia carrier in Bangladesh. Our objective is to identify the prevalence of beta-thalassemia in our adoles...

BACKGROUND In beta-thalassemia major, heart failure primarily affecting left ventricular systolic function is the most common complication and cause of death. Apart from iron deposition, it has been recently reported that myocarditis might be another contributing factor in the pathogenesis of acute or chronic heart failure, acting possibly through an autoimmune mechanism. In an attempt to asses...

beta-thalassemia major (β-tm) is a chronic, genetic and hematological disorder. children and teenagers with chronic physical illnesses exemplified by thalassemia are vulnerable to emotional and behavioral problems. the aim of this study was to evaluate mental health and its related factors among young patients with beta-thalassemia major.in this cross-sectional observational descriptive-analyti...

Thromboembolic events and hypercoagulable state have been reported in patients with thalassemia. As platelets play an important role in the pathogenesis of thrombosis, the authors aimed to find the pattern of changes in platelet count, function and activation, and evidence of coagulation activation in patients with thalassemia major in Indonesia. A total of 31 patients with splenectomized and 3...

background: hepatitis c virus (hcv) is the major cause of post-transfusion hepatitis infection (pth). patients with thalassemia major are at high risk of hepatitis c due to the blood transfusion from donors infected by hcv. the aim of this study was to detect the prevalence of anti-hcv antibodies and risk factors in multitransfused thalassemic patients in isfahan-iran to establish more preventi...

Hydroxyurea (HU) enhances fetal hemoglobin (Hb) production. An increase in total Hb level has been repeatedly reported during HU treatment in patients with sickle cell disease and in several patients with beta-thalassemia intermedia. Effects in patients with beta-thalassemia major are controversial. We now report a marked elevation of total Hb levels with HU that permitted regular transfusions ...

Beta-thalassemia is an inherited anemia in which synthesis of the hemoglobin beta-chain is decreased. Clinical features of beta-thalassemia include variably severe anemia and iron overload due to increased intestinal iron absorption, which may result in damage to vital organs. The hepatic peptide; hepcidin is a key regulator of iron metabolism in mammals. The present study aimed to determine th...