Background & Aims: This study was carried out to assess the effect of opium addiction on the incidence of different types of arrhythmias after acute myocardial infarction (AMI). Methods: The study population consisted of 200 patients with first AMI admitted within 6 hours of the onset of chest pain to the coronary care units (CCU) of two hospitals affiliated to Kerman University of Medical Scie...

background: the poisoning is mostly due to suicide and is observed in younger age groups. the systemic manifestations of alp poisoning are common but pernicious manifestations of them are cardiotoxicity, shock, and ards. the clinical hallmark of cardiotoxicity is arrhythmia. the aim of this study was to investigate cardiac arrhythmias in patients poisoned with alp who were admitted to razi hosp...

This mass-spectrometric method for assaying tocainide in serum is specific, reproducible, and sensitive, and sample preparation is rapid. The drug is isolated from serum by liquid-solid extraction on a Baker C18 disposable column. Underivatized drug is separated by elution on a 0.20 mm X 25 m fused-silica capillary column coated with 5% phenylmethylsilicone, then quantified by mass-selective de...

2. Atrial Fibrillation/Flutter: Most common use of Holter in this setting is to diagnose transient atrial fibrillation. There is a unique application of Holter ECG in atrial fibrillation, that is particularly in understanding the relationship to autonomically mediated atrial fibrillation. After the diagnosis has been made Holter is used to assist the efficacy of anti-arrhythmic drugs in suppres...

A 41-year-old man with a history of tachycardia refractory to multiple antiarrhythmic drugs was sent to our institution. His 12-lead electrocardiogram demonstrated incessant narrow QRS complex tachycardia with negative P waves in the inferior leads and long RP interval. Occasionally, the tachycardia terminated after a P wave and then was restarted after a sinusal beat. An EP study was performed...

The major limitation to antiarrhythmic drug therapy is the risk of arrhythmia promotion, or 'proarrhythmia.' This complication may be lethal, and greatly restricts the value of antiarrhythmic agents, particularly for arrhythmias without an intrinsic mortality risk, such as atrial fibrillation. In order for improved antiarrhythmic drug therapy to be developed, it is essential to understand the f...

The antiarrhythmic effectiveness and safety of 12-h oral administration of mexiletine were evaluated in adult outpatients with a baseline hourly rate of PVCs of 30 or higher who had initially shown at least a 50 percent reduction of this rate when treated with mexiletine at an 8-h dosage interval. Doses were titrated on the basis of 24-h Holter monitoring for both 8- and 12-h intervals. Sevente...

Triggered activity was shown to be the likely mechanism of recurrent tachycardia in a 28 year old Vietnamese man. During baseline electrophysiological testing the tachycardia was induced consistently by prolonged atrial or ventricular pacing but not by premature extrastimuli. Moreover, the tachycardia coupling intervals varied directly with the cycle length of the initiating drive. Procainamide...