نتایج جستجو برای: apobec3g

تعداد نتایج: 713  

Journal: :PLoS Pathogens 2005
Viviana Simon Veronique Zennou Deya Murray Yaoxing Huang David D Ho Paul D Bieniasz

The HIV-1 Vif protein counteracts the antiviral activity exhibited by the host cytidine deaminases APOBEC3G and APOBEC3F. Here, we show that defective vif alleles can readily be found in HIV-1 isolates and infected patients. Single residue changes in the Vif protein sequence are sufficient to cause the loss of Vif-induced APOBEC3 neutralization. Interestingly, not all the detected defects lead ...

Journal: :The Journal of biological chemistry 2012
Robin P Love Huixin Xu Linda Chelico

APOBEC3A belongs to a family of single-stranded DNA (ssDNA) DNA cytosine deaminases that are known for restriction of HIV through deamination-induced mutational inactivation, e.g. APOBEC3G, or initiation of somatic hypermutation and class switch recombination (activation-induced cytidine deaminase). APOBEC3A, which is localized to both the cytoplasm and nucleus, not only restricts HIV but can a...

Journal: :Journal of virology 2008
Marc-André Langlois Michael S Neuberger

APOBEC3 proteins are mammal-specific cytidine deaminases that can restrict retroviral infection. The exact mechanism of the restriction remains unresolved, but one model envisions that uracilated retroviral cDNA, generated by cytidine deamination, is the target of cellular glycosylases. While restriction is unaffected by UNG deficiency, it has been suggested that the SMUG1 glycosylase might pro...

Journal: :Journal of virology 2007
Marjorie Pion Romaine Stalder Rafael Correa Bastien Mangeat Greg J Towers Vincent Piguet

Dendritic cells are central to the early events of human immunodeficiency virus type 1 (HIV-1) transmission, but HIV-1 infects dendritic cells inefficiently in vitro compared to activated CD4(+) T cells. There is a strong postentry restriction of HIV-1 infection in dendritic cells, partly mediated by the cellular restriction factor APOBEC3G. Here, we reveal that arsenic trioxide markedly increa...

Journal: :Nature Reviews Immunology 2005

2016
Tegwinde Rebeca Compaore Serge Theophile Soubeiga Abdoul Karim Ouattara Dorcas Obiri-Yeboah Damehan Tchelougou Mamoudou Maiga Maleki Assih Cyrille Bisseye Didier Bakouan Issaka Pierre Compaore Augustine Dembele Jeremy Martinson Jacques Simpore William A Paxton

Studies on host factors, particularly the APOBEC3G gene, have previously found an association with AIDS progression in some populations and against some HIV-1 strains but not others. Our study had two main objectives: firstly, to screen a population from Burkina Faso for three variants of APOBEC3G previously described, and secondly to analyze the effect of these three variants and their haploty...

Journal: :Investigative ophthalmology & visual science 2009
Haotian Lin Zhenping Zhang Hui Zhang Pisong Yan Qilin Wang Ling Bai

PURPOSE To develop methods for primary culture of human blood-retinal barrier (BRB) cells and to explore the expression of APOBEC3 (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3) family gene, novel host-defense factors to HIV-1. METHODS Cellular components of human BRB (human retinal capillary endothelial cells [HRCECs], human retinal capillary pericytes, and human retina...

Journal: :Journal of virology 2004
Ping An Gabriela Bleiber Priya Duggal George Nelson Margaret May Bastien Mangeat Irene Alobwede Didier Trono David Vlahov Sharyne Donfield James J Goedert John Phair Susan Buchbinder Stephen J O'Brien Amalio Telenti Cheryl A Winkler

The cytosine deaminase APOBEC3G, in the absence of the human immunodeficiency virus type 1 (HIV-1) accessory gene HIV-1 viral infectivity factor (vif), inhibits viral replication by introducing G-->A hypermutation in the newly synthesized HIV-1 DNA negative strand. We tested the hypothesis that genetic variants of APOBEC3G may modify HIV-1 transmission and disease progression. Single nucleotide...

Journal: :The Journal of biological chemistry 2006
Andrew Mehle Elaine R Thomas Kottampatty S Rajendran Dana Gabuzda

Human immunodeficiency virus-1 (HIV-1) Vif overcomes the anti-viral activity of APOBEC3G by targeting it for ubiquitination via a Cullin 5-ElonginB-ElonginC (Cul5-EloBC) E3 ligase. Vif associates with Cul5-EloBC through a BC-box motif that binds EloC, but the mechanism by which Vif selectively recruits Cul5 is poorly understood. Here we report that a region of Vif (residues 100-142) upstream of...

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