نتایج جستجو برای: anergy
تعداد نتایج: 1795 فیلتر نتایج به سال:
Tuberculosis (TB) is the second leading cause of death WORLDWIDE from a single infectious pathogen. Despite the fact that the majority of TB cases are in developing countries, this disease is also a problem in industrialized nations, such as the United States. Mycobacterium tuberculosis infects approximately 15 million people in this country, although it causes disease in many fewer. Even thoug...
Experiments in various models have indicated that immunological tolerance can result from the physical elimination (deletion) of reactive lymphocytes as well as from anergy. We have previously reported that mature CD4-CD8+ T cells when confronted with their antigen can proliferate extensively but are finally eliminated or become intrinsically anergic such that remaining cells are refractory to ...
Depletion of CD4+ cells using anti-CD4 monoclonal antibodies leads to allograft tolerance. Here we show that anti-CD4-mediated tolerance to pancreatic islets of Langerhans transplanted from an A/J (IEk) donor to a diabetic C57B1/6 (B6) (IE-) recipient occurs in the absence of clonal deletion of the potentially IE-reactive V beta 11+ T cells. Instead, a state of clonal anergy is induced in both ...
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