The amnesic population provides a unique opportunity to examine the reliability of clinical tests because amnesics do not consciously recollect initial testing sessions. In this study, amnesic subjects were studied to examine the reliability between the Minnesota Multiphasic Personality Inventory (MMPI) and the MMPI-2. Findings indicated that there were no statistical differences between versio...

In the present communication, we have investigated effects of the CDRI-08, a well characterized extract of Bacopa monnieri, on expression of the GluN2B subunit of NMDAR in various brain regions of the scopolamine-induced amnesic mice. Our behavioral data reveal that scopolamine-treated amnesic mice exhibit significant decline in the spatial memory compared to the normal control mice. Our RT-PCR...

Habit learning has been defined as an association between a stimulus and a response that develops slowly and automatically through repeated reinforcement. Concurrent discrimination (CD) learning, in which subjects learn to choose the rewarded objects in a series of pairs, is believed to be an example of habit learning in monkeys. Studies of human amnesic subjects, however, have produced equivoc...

A category classification test was used to differentiate between normal student eontrol participant.~. students instructed to malinger a memory deficit, and amnesic" patients. Controls (N = 44) and amnesic patients (N = 10) were instructed to do their best, while simulators of malingering (N = 43) were instructed to fake a memory deficit for credit and possible financial compensation. Partieipa...

BACKGROUND The cholinergic nucleus basalis (Ch4) is an exclusive site of neurofibrillary degeneration in alcoholic patients with Wernicke's encephalopathy. AIM To test the hypothesis that the loss of Ch4 neurons contributes to the memory disorder, Korsakoff's psychosis, commonly seen in Wernicke's encephalopathy. METHODS Magnocellular basal forebrain neurons were quantified in alcoholic pat...

Relational memory theory holds that the hippocampus supports, and amnesia following hippocampal damage impairs, memory for all manner of relations. Unfortunately, many studies of hippocampal-dependent memory have either examined only a single type of relational memory or conflated multiple kinds of relations. The experiments reported here employed a procedure in which each of several kinds of r...

We assessed priming of new associations in amnesic patients and healthy control subjects in a paradigm developed by Graf and Schacter (1985). Subjects were presented unrelated word pairs embedded in sentences (e.g., A BELL was hanging over the baby's CRADLE) and were asked to rate how well the sentences related the two words. Subjects were then given a word completion test. They were shown thre...

BACKGROUND Cognitive disorders associated with aging have been successfully managed by African traditional medical practitioners using various plants. This study evaluated the cognitive enhancing potentials of Morinda lucida (L) Rubiaceae and Peltophorum pterocarpum (DC) ex. K Heyne in scopolamine induced amnesic animals. MATERIALS AND METHODS The anti-amnesic activity of the ethyl acetate ex...

Can associative learning take place without awareness? We explore this issue in a sequence learning paradigm with amnesic and control participants, who were simply asked to react to one of four possible stimuli on each trial. Unknown to them, successive stimuli occurred in a sequence. We manipulated the extent to which stimuli followed the sequence in a deterministic manner (noiseless condition...

Nine amnesic patients of mixed aetiology were studied in a duration-judgement task that allowed three measures of memory to be obtained. On each trial of the task, subjects attempted to read a briefly flashed word and to estimate the duration of the flash. Both word identification and duration estimation differed as a function of prior study. Words that were previously studied were identified m...