The feeding of p-aminobenzoic or cr-amino-y-phenylbutyric acid to rats results in the excretion of acetylaminobenzoic or acetylphenylaminobutyric acid in the urine. Simultaneous feeding of isotopically labeled compounds such as acetic or pyruvic acid (1, 2), Dor L-alanine (3), Dor L-serine (4), or an acetylaminol acid (5) gives rise to labeled acetyl groups. Whereas most combinations of acetyl ...

The shikimate pathway presents an attractive target for malaria chemotherapy. Three shikimic acid analogs exhibited different effects on Plasmodium falciparum growth. (6R)-6-Fluoro-shikimate and (6S)-6-fluoro-shikimate inhibited growth (50% inhibitory concentrations, 1.5 x 10(-5) and 2.7 x 10(-4) M, respectively), whereas 2-fluoro-shikimate had no effect. para-Aminobenzoic acid abrogated the in...

aminocarboxylic acids, such as 2-aminobenzoic acid, react easily with [ir(cod)(pme3)3]cl, (cod=1,5-cyclooctadiene), in thf to produce hydridoaminocarboxylato iridium(iii) complexes in high yields. these octahedral complexes are formed via oxidative addition reaction of the o-h bond of the carboxylic group with the central metal. the starting iridium(i) complex losses the cod molecule, the chlor...