نتایج جستجو برای: alkaline comet assay
تعداد نتایج: 265321 فیلتر نتایج به سال:
Background and purpose : Ënhanced sensitivity to the chromosome-damaging effects of ionizing radiation is a feature of many cancer-predisposing conditions. Ïn this study we compared the radiation sensitivity of breast cancer patients and healthy volunteers by measuring the levels of initial DNÂ damage in peripheral leukocytes using the comet assay (single-cell alkaline gel electrophoresis). ...
In the present study we analyzed and followed-up on the DNA damaging effects of microwave radiation of GEM radar equipment within microwave field of 10 μW/cm to 10 mW/cm in personnel occupationally exposed to frequency range of 1.5 GHz to 10.9 GHz. The single cell gel electrophoresis (SCGE)/comet assay as a tool for the biomonitoring of individuals accidentally, environmentally or occupationall...
The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally validated. The Japanese Center for the Validation of Alternative Methods (JaCVAM), with the cooperation of the U.S. NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NIC...
PURPOSE Repair of radiation-induced DNA damage plays a critical role for both the susceptibility of patients to side effects after radiotherapy and their subsequent cancer risk. The study objective was to evaluate whether DNA repair data determined in vitro are correlated with the occurrence of acute side effects during radiotherapy. EXPERIMENTAL DESIGN Nasopharyngeal cancer patients receivin...
The aim of this study was to evaluate the genetic damage in human peripheral blood lymphocytes following 24 and 48- hour exposure to a commercial diazinon formulation Basudin 60EM® at concentrations between 0.01 and 40 μg mL-1. For this purpose we used the micronucleus (MN), fluorescence in situ hybridization (FISH), and alkaline single cell gel electrophoresis (comet) assay. Diazinon significa...
normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : cotoneaster discolor and alhagi pseudalhagi are two important kinds of iranian manna. they have several therapeutic applications in adults and children. the most important ingredient of cotoneaster discolor is mannitol. due to the scarcity of toxicological studies on these compounds, their genotoxicity was e...
abstractbackground: radioprotective effects of famotidine, an antagonist of h2 receptor clinically used for peptic ulcer treatment, was previously shown on radiation-induced micronuclei and chromosomal aberration in human peripheral blood lymphocytes and mouse bone marrow cells. this study was conducted to investigate radioprotective property of famotidine against radiation induced apoptosis in...
Mineral trioxide aggregate (MTA) and Portland cement are being used in dentistry as root end-filling materials. However, biocompatibility data concerning genotoxicity and cytotoxicity are needed for complete risk assessment of these compounds. In the present study, genotoxic and cytotoxic effects of MTA and Portland cements were evaluated in vitro using the alkaline single cell gel (comet) assa...
Cattley guava (Psidium cattleyanum Sabine) is a native fruit of Brazil that is popular both as a sweet food and for its reputed therapeutic properties. We examined whether it could damage DNA using the alkaline single-cell gel electrophoresis (comet assay) and the micronucleus test in leukocytes and in bone marrow cells of mice. P. cattleyanum leaf extract was tested at concentrations of 1000, ...
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