Sai-Juan Chen, * Arthur Zelent, * Jian-Hua Tong, * Huai-Qin Yu, * Zhen-Yi Wang, * Josette Derre,1 Roland Berger,' Samuel Waxman,11 and Zhu Chen* *Shanghai Institute ofHematology, Rui-Jin Hospital, Shanghai Second Medical University, and Shanghai Central Railway Hospital, Shanghai 200025, China; *Leukaemia Research Fund Center at the Institute ofCancer Research, Chester Beatty Laboratories, Fulh...

Background: Acute promyelocytic leukemia (APL) is a unique subtype of acute leukemia’s. It has distinct Cytogenetics, clinical features, and biologic characteristics. Acute promyelocytic leukemia (APL) is caused by an arrest of leukocyte differentiation at the promyelocytic stage. The discovery and elucidation of the molecular pathogenesis for APL has led to first and only targeted therapy for ...

In the human promyelocytic cell line HL60, we observed both a strong procoagulant activity (PCA) on the cell membrane and proteolytic activity in the lysate of these cells. Because these cell-line cells are susceptible to differentiation to either a more mature granulocytic or monocytic form, we were able to study the hypothesis that the combination of PCA and proteolytic activity is confined t...

Acute promyelocytic leukemia (APL) represents 15 % of acute myeloid leukaemia. Prior to tretinoin usage, the treatment of APL was difficult and remission rates were low especially in developing countries due to mortality resulting primarily from bleeding'. APL is associated with a coagulopathy which may be due to a combination of disseminated intravascular coagulation and primary fibrinolysis. ...

A 32-year-old Hispanic male with a history of acute pro myelocytic leukemia (APL) in complete remission presented with increasing fatigue and mild dyspnea. His previous diagnosis of APL was made 2 years ago (Figure 1). Cytogenetic evaluation at the time of diagnosis demonstrated the presence of a reciprocal translocation between chromosomes 15 and 17, t(15;17), and the promyelocytic/retinoic ac...