Three new 2-pyranone derivatives, namely Norcardiatones A (1), B (2) and C (3), were isolated from the agar cultures of the strain Nocardiopsis sp. A00203, a mangrove endophytic actinomycete. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HR Q-TOFMS. Compound 1 showed week cytotoxicity against HeLa cells in MTT assay.

The actinomycete Nocardiopsis alba was reportedly associated with honeybees in separate occurrences. We report the complete genome of Nocardiopsis alba ATCC BAA-2165 isolated from honeybee guts. It will provide insights into the metabolism and genetic regulatory networks of this genus of bacteria that enable them to live in a range of environments.

Ivermectin (MK-0933, 22, 23-dihydroderivative of amvermectin B1) is a synthetic derivative of a broadspectrum antiparasitic class of macro cyclic lactones known as avermectins. Avermectin B was first isolated by fermentation of a soil microorganism, the actinomycete Streptomyces avermitilis. Ivermectin has a structure similar to that of macrolide antibiotics, but without antibacterial activity ...

Clavibacter michiganensis subsp. sepedonicusis is a Gram-positive actinomycete that is the causative agent of the potato disease ring rot. Here, we announce the complete genome sequence of the Clavibacter michiganensis subsp. sepedonicusis siphophage CN1A. CN1A is only the second fully sequenced Clavibacter michiganensis subsp. sepedonicusis phage reported to date. Core and unique features of i...

Paenarthrobacter nicotinovorans Hce-1 is a Gram-positive obligate aerobe actinomycete. We report here the complete genome sequence of this organism. The genome has a length of 4,174,362 bp and contains 4,568 protein-coding genes, 64 tRNA operons, and 22 rRNA operons. Its GC content in the gene region is 63.4%.

A new thiolactone-containing antibiotic U-68,204 was found to be produced by a soil actinomycete identified as Streptomyces thiolactonus UC 8478 (NRRL 15,439). The production, isolation, structure determination as well as the physical, spectroscopic and antibacterial properties of this C13H17NO3S compound are here reported. On the basis of these data, the antibiotic was identified as the 10-car...

A new antibiotic SF-2185 was found active against plant pathogen, particularly the causal organisms of cucumber downy mildew and rice blast. The producing organism, strain SF-2185, is a novel actinomycete and has been identified as Dactylosporangium aurantiacum subsp. gifuense.

Three new 10-membered macrolides, saccharothriolides A-C (1-3), were discovered from a rare actinomycete Saccharothrix sp. A1506. All of the sp(3) carbons in the 10-membered ring had chirality, which was determined by extensive spectroscopic analysis and TDDFT-calculation of ECD spectra. Saccharothriolide B (2) exhibited cytotoxicity against human tumor cell lines HeLa and HT1080.

A novel actinomycete strain, designated YIM 30243T, was isolated from a soil sample in Yunnan Province, China. Based on the results of phenotypic and genotypic characteristics, strain YIM 30243T should be assigned to a new species of the genus Nocardia, for which the name Nocardia alba sp. nov. is proposed. The type strain is YIM 30243T (= CCTCC AA001030T = DSM 44684T).

A mutualist actinomycete of the southern pine beetle, Dendroctonus frontalis, produces a polyene peroxide with pronounced antifungal activity. Its structure, absolute configuration, and biological activity were determined by spectral analysis, chemical modification followed by the modified Mosher method, and growth inhibitory assays, respectively.