The young kitten has proved to be a suitable experimental animal for studying in vivo effects of oxygen on immature retinal vessels. Visualization of these vessels by ophthalmoscopy, however, is unsatisfactory. A method is presented which affords good visualization of the retinal vessels by fluorescein angiography and which permits precise control of the intraocular pressure by use of an artifi...

—The main cause of eye diseases in the working human is Diabetic retinopathy. Eye disease can be prevented if detects early. The extraction of blood vessels from retinal images is an essential and challenging task in medical diagnosis and analysis. This paper describes the effective and efficient extraction of blood vessels from retinal image by using Kirsch’s templates. The Kirsch’s edge opera...

T HE PHYSIOPATHOLOGY of the retinal vasculature would be better understood if more were known about blood flow in these vessels. Because of the unique quality of transparency in the eye, methods depending on direct observation of the retinal vessels seem especially inviting. Already reported by various authors are technics for measuring the changes in caliber of retinal vessels,1 and methods of...

PURPOSE Signal transducer and activator of transcription protein-3 (STAT3) is a transcription factor that participates in many biological processes, including tumor angiogenesis. The expression and activation of Stat3 in the mouse model of ischemia-induced retinal neovascularization was investigated to evaluate the possible role of STAT3 in retinal vascular disease. METHODS Retinal neovascula...

In babies who are born preterm (before 37 weeks), the retinal blood vessels are not fully formed and do not reach the ora serrata (Figure 2). If a preterm baby is examined a week or so after birth, it is possible to see whether the blood vessels are mature and have reached the ora serrata, or whether they are immature; i.e., the peripheral retina is not vascularised. If babies receive good neon...

PURPOSE The purpose of this study was to identify ways to improve qualitative and quantitative assessments of retinal vessels and neovascularization (NV). METHODS At postnatal day (P) 17, mice with oxygen-induced ischemic retinopathy were injected intravitreously with one of a variety of FITC-labeled or unlabeled antibodies and humanely killed 12 hours later. Retinas were flat mounted (retina...

Retinal images play vital role in several applications such as disease diagnosis and human recognition. They also play a major role in early detection of diabetics by comparing the states of the retinal blood vessels. The detection of blood vessels from the retinal images is a tedious process. In this work a new algorithm to detect the blood vessels effectively has been proposed. Initially enha...

The extraction of blood vessels from retinal images is an important and challenging task in medical analysis and diagnosis. This paper presents a novel hybrid automatic approach for the extraction of retinal image vessels. The method consists in the application of mathematical morphology and a fuzzy clustering algorithm followed by a purification procedure. In mathematical morphology, the retin...