نتایج جستجو برای: abcg1 abcg5 pyy 3

تعداد نتایج: 1812486  

Journal: :The Journal of clinical investigation 2002
Gregory A Graf Wei-Ping Li Robert D Gerard Ingrid Gelissen Ann White Jonathan C Cohen Helen H Hobbs

Mutations in either ATP-binding cassette (ABC) G5 or ABCG8 cause sitosterolemia, an autosomal recessive disorder of sterol trafficking. To determine the site of action of ABCG5 and ABCG8, we expressed recombinant, epitope-tagged mouse ABCG5 and ABCG8 in cultured cells. Both ABCG5 and ABCG8 underwent N-linked glycosylation. When either protein was expressed individually in cells, the N-linked su...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Claudio Acuna-Goycolea Anthony N van den Pol

Peptide YY(3-36) (PYY(3-36)) is released by endocrine cells of the gut and may serve as an important long-distance neuropeptide signal relating energy balance information to the brain to depress food intake. The postulated mechanism is the activation of anorexigenic proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus. In striking contrast, using voltage and current-clamp reco...

Journal: :American journal of physiology. Endocrinology and metabolism 2008
June Zhou Roy J Martin Richard T Tulley Anne M Raggio Kathleen L McCutcheon Li Shen Samuel Colby Danna Sasmita Tripathy Maren Hegsted Michael J Keenan

Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) are anti-diabetes/obesity hormones secreted from the gut after meal ingestion. We have shown that dietary-resistant starch (RS) increased GLP-1 and PYY secretion, but the mechanism remains unknown. RS is a fermentable fiber that lowers the glycemic index of the diet and liberates short-chain fatty acids (SCFAs) through fermentation in the gut...

Journal: :Journal of immunology 2012
David W Draper Kymberly M Gowdy Jennifer H Madenspacher Rhonda H Wilson Gregory S Whitehead Hideki Nakano Arun R Pandiri Julie F Foley Alan T Remaley Donald N Cook Michael B Fessler

Mice with genetic deletion of the cholesterol transporter ATP binding cassette G1 (ABCG1) have pulmonary lipidosis and enhanced innate immune responses in the airway. Whether ABCG1 regulates adaptive immune responses to the environment is unknown. To this end, Abcg1(+/+) and Abcg1(-/-) mice were sensitized to OVA via the airway using low-dose LPS as an adjuvant, and then challenged with OVA aer...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2008
Melissa H Nagelin Suseela Srinivasan Jianyi Lee Jerry L Nadler Catherine C Hedrick

OBJECTIVE The purpose of this study was to evaluate the effect of 12/15-lipoxygenase (12/15LO) in macrophage ABCG1 expression and function associated with cholesterol efflux. METHODS AND RESULTS 12/15LO was stably overexpressed in J774 macrophages. 12/15LO-overexpressing macrophages had a 30% reduction in HDL-mediated cholesterol efflux, corresponding with significantly reduced ABCG1 protein ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2006
Nan Wang Mollie Ranalletta Fumihiko Matsuura Felix Peng Alan R Tall

OBJECTIVE This study examines the ABCG1-mediated cholesterol efflux and intracellular cholesterol transport by studying the ABCG1 localization and function in macrophages. METHODS AND RESULTS HEK 293 cell overexpressing ABCG1, RNA interference, or macrophages from ABCG1 or ABCG4 knockout mice were used. ABCG1 but not ABCG4 had a major role in the increased cholesterol mass efflux produced by ...

Journal: :Diabetes 2006
Prasanth K Chelikani Alvin C Haver Roger D Reidelberger

Ghrelin stimulates, while glucagon-like peptide-1 (GLP-1) and peptide YY(3-36) [PYY(3-36)] inhibit, food intake and gastric emptying in rats. We determined the dose-dependent effects of a 3-h intravenous infusion of ghrelin at dark onset on food intake in freely feeding rats, and on the inhibitory effects of intravenous infusion of GLP-1 and PYY(3-36) on food intake and gastric emptying. Ghreli...

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2008
Yoshihiko Hirotani Kyoko Mikajiri Kenji Ikeda Michiaki Myotoku Nobuo Kurokawa

Few studies have reported the changes in the peptide YY (PYY) levels in the intestinal tissue of rats with ulcerative colitis (UC) following oral administration of mesalazine and prednisolone. We investigated the effects of these drugs on the intestinal mucosal PYY levels in a rat model of UC. We confirmed that the PYY levels in the rat intestinal mucosal tissue were high in the lower intestina...

Journal: :The Journal of biological chemistry 2010
Dan Li Duan Wang Yun Wang Wenhua Ling Xiang Feng Min Xia

Increasing evidence suggests that adenosine monophosphate-activated protein kinase (AMPK) exerts protective effects for cardiovascular diseases apart from the regulation of energy homeostasis. However, the role of AMPK and its underlying mechanism on macrophage foam cell formation are poorly understood. In this study, we sought to investigate the potential effects of AMPK in modulating choleste...

2017
Elvis Pandzic Ingrid C. Gelissen Renee Whan Philip J. Barter Dmitri Sviridov Katharina Gaus Kerry-Anne Rye Blake J. Cochran

The ATP-binding cassette sub-family G member 1 (ABCG1) exports cellular cholesterol to high-density lipoproteins (HDL). However, a number of recent studies have suggested ABCG1 is predominantly localised to intracellular membranes. In this study, we found that ABCG1 was organized into two distinct cellular pools: one at the plasma membrane and the other associated with the endoplasmic reticulum...

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