The possibility of inducing Parkinson's syndrome in cats was investigated in three kinds of lesions: by microinjection of 6-hydroxy dopamine (6-OHDA) into the pars compacta of substantia nigra (SNC), bilateral injection into the SNC and globus pallidus (GP) and into the SNC and caput nuclei caudati (NC). In all three kinds of lesions of the dopaminergic system disturbances of behavior involving...

Submit Manuscript | http://medcraveonline.com Abbreviations: 5-HT: 5 Hydroxy Triptamine; AD: Alzheimer Disease; Aβ: Amyloid-β; Aβ 1-42 and Aβ 1-40: Shorter peptides of Aβ released during pathogenesis; ApoE: Apolipoprotein E; CI: Cognitive Impairment; CMV: Cytomegalovirus; CRP: C Reactive Protein; CSF: Cerebrospinal Fluid; CSN: Central Nervous System; DA: Dopamine; EBV Epstein-Barr Virus; GF: Ge...

The neuropeptide substance P is known to have mnemogenic and reinforcing actions and can exert neurotrophic and regenerative effects in vitro as well as in vivo. Furthermore, our previous work in the rat showed that either pre- or post-lesion treatment with substance P can promote functional recovery in cases of partial nigrostriatal dopamine lesions. Other work has provided evidence that the e...