The solvent-free reactions of β-enamino carbonyl compounds with 1-(pyridin-2-yl)-enones in the presence of manganese(iii) acetate dihydrate unexpectedly afforded 2-acyl-3-aryl-6,7-dihydro-4(5H)-benzofuran derivatives under mechanical milling conditions.

! " # $% & ' ( *)+ %, ,. / 0 1 23)4 56 7 8 2 , * ,9 7 ,. 2 *:;-8 $ $<5=9 7$ *1 >:? .@ * ,* 9 2 ,A& $ :? B * B C , , " 2EDF < )G 5H & I ,* 7 J.@ 9 7 ( 2 $ I 7 8 9 K .LM G . N * " H ,* :; * & -

To determine whether Aloe vera (AV), a traditional herbal medicine, could maintain homeostasis, we investigated its ability to regulate the production of hormones, particularly thyroid hormones. T4 ELISA assay with (6H media) and without thyrotropin (TSH) (5H showed that AV functions endocrine homeostasis. understand mechanisms by which regulates thyroxine release, confirmed protein expression ...

A new synthetic approach to the 1,2,5-oxadiazine ring system is described. 2-Substituted or 2,4-disubstituted 2H-1,2,5-oxadiazine-3,6(4H,5H)-dione derivatives 4 were prepared by cyclisation of hydroxamic acids 3 derived from N-(1-benzotriazolylcarbonyl)-amino acids 1. The structures of the synthesised compounds were fully characterised by IR, 1H and 13C NMR spectroscopy and elemental analysis. ...

Several dibenzodiazepine derivatives were identified as novel retinoid X receptor (RXR) antagonists on the basis of inhibitory activity on retinoid-induced cell differentiation of human promyelocytic leukemia cells HL-60 and transactivation assay using retinoic acid receptors (RARs) and RXRs in COS-1 cells. 4-(5H-2,3-(2,5-Dimethyl-2,5-hexano)-5-n- propyldibenzo[b,e][1,4]diazepin-11-yl)benzoic a...

Transcription factor GATA2 is expressed in numerous mammalian tissues, including neural, hematopoietic, cardiovascular and urogenital systems, and yet it plays important roles in the regulation of tissue-restricted gene expression. The Gata2 gene itself is also under stringent tissue-specific control and multiple cis-regulatory domains have been identified in the Gata2 locus. In this study we s...

The photocatalytic activity of carbon nitride (CN) materials is mainly limited to small specific surface areas, solar absorption, and low separation mobility photoinduced carriers. In this study, we developed a precursor-modified strategy for the synthesis graphitic CN with highly efficient performance. precursor dicyandiamide reformed by different acids undergoes basic structural change transf...

Genipin was reacted with benzylamine and several amino acids to prepare gardenia blue (GB). The time-course of GB formation monitored by high-performance liquid chromatography (HPLC), time-of-flight mass spectrometry (LC-TOFMS), 1H 13C NMR measurements. In this experiment, we determined the molecular structures some intermediates using accurate masses additional techniques such as heteronuclear...

The non-benzenoid aromatic D(5h) and enediolate C(2v) form of C5O5(2-) have been stabilized by hydrogen bonding with urea and 1,3-dimethylurea, respectively, in the host lattices of two novel crystalline inclusion compounds.