We propose a mechanism, based on a > or =10-micros molecular dynamics simulation, for the surprising misfolding of hen egg-white lysozyme caused by a single mutation (W62G). Our simulations of the wild-type and mutant lysozymes in 8 M urea solution at biological temperature (with both pH 2 and 7) reveal that the mutant structure is much less stable than that of the wild type, with the mutant sh...

Purpose: Increasing evidence indicates that enhanced intratumoral androgen synthesis contributes to prostate cancer progression after androgen deprivation therapy. This phase II study was designed to assess responses to blocking multiple steps in androgen synthesis with inhibitors of CYP17A1 (ketoconazole) and type I and II 5α-reductases (dutasteride) in patients with castration-resistant prost...

This paper introduces the multiarmed bandit problem with deadlines, which concerns the dynamic selection of a live project to engage out of a portfolio of Markovian bandit projects expiring after given deadlines, to maximize the expected total discounted or undiscounted reward earned. Although the problem is computationally intractable, a natural heuristic policy is obtained by attaching to eac...

Linguistics is, perhaps, the only field of scientific studies two colleagues, who were companions on Siberian journey – D. G. Messerschmidt and Ph. J. Strahlenberg in which historians science cannot reach consensus whom give palm title pioneer study languages peoples whose contribution formation comparative linguistics was more significant. The article presents materials from personal collectio...

The research is focused on the topographic modelling and mapping of Aleutian Trench. study area situated in Bering Sea, a marginal sea located northernmost Pacific Ocean, between Alaska Kamchatka Peninsula. geological setting region characterized by subduction oceanic Plate below continental North American Plate. Other features include high seismic activity along island arcs bordering seafloor....

and many clinicians overcame the stultifying effects of the Brunonian theory. Francesco Torrigiani sought post-mortem confirmation of his bedside diagnoses, and Antonio Catellacci wrote a good account of the yellow fever-although Torrigiani accused him of plagiarizing it. Amongst the twenty short biographies is one of Giuseppe Bertini (1722-1845), the first professor of the philosophical histor...

We construct a simple firm-based automata model for global economic inter-dependence of countries using modern notions of self-organized criticality and recently developed dynamical-renormalization-group methods (e.g., L. Pietronero et al., Phys. Rev. Lett., 72(11):1690 (1994); J. Hasty and K. Wiesenfeld, Phys. Rev. Lett., 81(8):1722, (1998)). We demonstrate how extremely strong statistical cor...

and many clinicians overcame the stultifying effects of the Brunonian theory. Francesco Torrigiani sought post-mortem confirmation of his bedside diagnoses, and Antonio Catellacci wrote a good account of the yellow fever-although Torrigiani accused him of plagiarizing it. Amongst the twenty short biographies is one of Giuseppe Bertini (1722-1845), the first professor of the philosophical histor...