Wind is an abundant, yet intermittent, source of renewable energy, with speeds changing both spatially and temporally over a wide range time scales. While wind variability well documented on large meteorological scales the behavior turbulent flow at high frequencies understood, there remain questions in literature regarding intermediate region these domains. Understanding microscale, here consi...

Experimental Biology and Medicine Magnus M. Berglund, Philip A. Hipskind and Donald R. Gehlert Peptide Receptor Subtypes Recent Developments in Our Understanding of the Physiological Role of PP-Fold 2003, 228:217-244. Experimental Biology and Medicine http://ebm.rsmjournals.com/content/228/3/217 Updated information and services can be found at: http://ebm.rsmjournals.com/content/228/3/217#BIBL ...

Triple negative breast cancer (TNBC) is one of the most aggressive breast cancers without effective targeted therapies. Numerous studies have implied that KLF5 plays an important roles in TNBC. How is KLF5 regulated by microRNAs has not been well studied. Here, we demonstrated that miR-217 down-regulates the expression of KLF5 and KLF5's downstream target gene FGF-BP and Cyclin D1 in TNBC cell ...

Following the failure of PROWESS-SHOCK to demonstrate efficacy, Eli Lilly and Company withdrew drotrecogin alfa (activated) from the worldwide market. Drotrecogin was initially approved after the original trial, PROWESS, was stopped early for overwhelming efficacy. These events prompt consideration of both the initial approval decision and the later decision to withdraw. It is regrettable that ...

Thallium (81(217)Tl, Bismuth (83(217)Bi), Astatine (85(217)At), Francium (87(217)Fr), Actinium (89(217)Ac) and Protactinium (91(217)Pa) are of odd-proton numbers among the mass chain A = 217. In the present work, the half-lives and gamma transitions for the six nuclei have been studied and adopted based on the recently published interactions or unevaluated nuclear data sets XUNDL. The Q (α) has...

Lack or downregulation of the dopamine D2 receptor (D2R) increases the vulnerability to renal inflammation independent of blood pressure in mice. Common single nucleotide polymorphisms (SNPs) rs6276, 6277, and 1800497 in the human D2R gene are associated with decreased receptor expression/function and hypertension. Human renal proximal tubule cells from subjects carrying these SNPs have decreas...