Although support vector machine (SVM) has become a powerful tool for pattern classification and regression, a major disadvantage is it fails to exploit the underlying correlation between any pair of data points as much as possible. Inspired by the modified pairwise constraints trick, in this paper, we propose a novel classifier termed as support vector machine with hypergraph-based pairwise con...

Writing Committee: Peter E. Clayton, Royal Manchester Children’s Hospital, Manchester, United Kingdom; Walter L. Miller*, University of California, San Francisco, California; Sharon E. Oberfield, Columbia University, New York, New York; E. Martin Ritzén, Karolinska Institute, Stockholm, Sweden; Wolfgang G. Sippell*, University Children’s Hospital, Kiel, Germany; Phyllis W. Speiser, New York Uni...

Received: April 1, 2009 Accepted: May 13, 2009 Correspondence: Dr. Keisuke Nagasaki, Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medicine and Dental Sciences, 1-757 Asahimachi, Niigata 951-8510, Japan E-mail: [email protected] H62L Mutation of CYP21A2 Identified in the Non-classical Form of 21-Hydroxylase Deficiency

BACKGROUND Failure in the DNA mismatch repair system is commonly accompanied by microsatellite instability and leads to colorectal cancer. The aim of this study was to find the most frequent of five mononucleotide markers in order to devise the simplest diagnostic strategy for identification of patients with hereditary nonpolyposis colorectal cancer (HNPCC) who were defined by defects in mismat...

We present a pilot study of extragalactic HI 21-cm absorption lines using the Five-hundred-meter Aperture Spherical radio Telescope (FAST). observed 5 continuum sources with features firstly identified in 40% data release Arecibo Legacy Fast L-Band Feed Array (ALFA) Survey (ALFALFA), including two systems later detected by Westerbork Synthesis Radio (WSRT). Most our observations were carried ou...