نتایج جستجو برای: 17b
تعداد نتایج: 472 فیلتر نتایج به سال:
To the Editor: The prognosis of HIV infection has dramatically changed following the introduction of highly active antiretroviral therapy (HAART), a multidrug regimen usually consisting of three to four antiretroviral drugs belonging to the categories of nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs) and of protease inhibitors (PIs). The somewhat remarkable th...
Estrogens stimulate the proliferation of many breast tumors and cell lines derived from them. Antiestrogens have therefore become a powerful therapeutic agent to treat breast tumors that express estrogen receptor (ER) a. In addition, aromatase inhibitors are now used in postmenopausal women to block the in situ conversion of adrenal androgens to estrogens. This approach can only be successful i...
The initial step in HIV-1 infection occurs with the binding of cell surface CD4 to trimeric HIV-1 envelope glycoproteins (Env), a heterodimer of a transmembrane glycoprotein (gp41) and a surface glycoprotein (gp120). The design of soluble versions of trimeric Env that display structural and functional properties similar to those observed on intact viruses is highly desirable from the viewpoint ...
The aim of the present study was to investigate the possible contribution of estrogen to pregnancy-associated modulation of nitric oxide production in the human myometrium during pregnancy. Both endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) proteins were clearly expressed in the non-pregnant myometrium and were elevated in the ®rst trimester of pregnancy. Oral contraceptive ...
The interleukin-17B receptor (IL-17BR) is expressed in a variety of tissues and is upregulated under inflammatory conditions. This receptor binds both its cognate ligand IL-17B and IL-17E/IL-25, a novel cytokine known to promote Th2 responses. The present study illustrates that airway smooth muscle cells express IL-17BR in vitro and that its expression is upregulated by TNFα and downregulated b...
Alveolar Echinococcosis (AE) caused by the cestode Echinococcus multilocularis, is a severe helminth infection of man, where unrestricted parasite growth will ultimately result in organ failure and fatality. The tissue-infiltrative growth of the larval metacestode and the limited efficacy of available drugs complicate successful intervention in AE; patients often need life-long medication, and ...
C-di-GMP is a second messenger in bacteria and partly regulates bacterial physiology by binding to class I and II riboswitches. Four class I c-di-GMP riboswitch aptamer candidates, Ct-E88, Cb-17B, Cb-E43 and Cd-630 RNAs, selected from a GEMM RNA sequence motif in the Rfam database, were expressed and experimentally verified to bind to c-di-GMP. The two newly characterized c-di-GMP riboswitches,...
Two hopanoids, 17b(H),21b(H)-hop-22(29)-ene (diploptene) and 17b(H),21b(H)-bishomohopanoic acid (bbC32HA), are the most abundant among the pentacyclic triterpenoids found in Recent sediments of the Paci®c Ocean alongside the Japanese Islands. The concentration of diploptene normalized to organic carbon content is higher in sediments where C37 polyunsaturated alkene (a biomarker of Haptophytes) ...
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