نتایج جستجو برای: 155

تعداد نتایج: 14701  

2016
Zhengxu Cai Song Li Sheng Li Fan Song Zhen Zhang Guanhua Qi Tianbai Li Juanjuan Qiu Jiajia Wan Hua Sui Huishu Guo

Epilepsy is a severe brain disorder affecting numerous patients. Recently, it is inferred that modulation of microRNA-155 (miR-155) could serve as a promising treatment of mesial temporal lobe epilepsy. In the current study, the therapeutic potential of miR-155 antagonist against temporal lobe epilepsy (TLE) was evaluated and the underlying mechanism involved in this regulation was explored. TL...

Journal: :Investigative ophthalmology & visual science 2010
Mohamed Nassr Xiangdi Wang Suchareeta Mitra Natalie E Freeman-Anderson Renukadevi Patil C Ryan Yates Duane D Miller Eldon E Geisert

PURPOSE. To investigate the effectiveness of a novel isoquinoline derivative, EDL-155, in killing retinoblastoma in vitro and in vivo. METHODS. Dose-response curves were generated in which Y79 retinoblastoma cells tagged with luciferase (Y79-Luc) were treated with serial concentrations of EDL-155. Electron microscopy was used to evaluate the ultrastructural morphology of EDL-155-treated Y79 cel...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Sukhinder K Sandhu Stefano Volinia Stefan Costinean Marco Galasso Reid Neinast Ramasamy Santhanam Mark R Parthun Danilo Perrotti Guido Marcucci Ramiro Garzon Carlo M Croce

Multiple studies have established that microRNAs (miRNAs) are involved in the initiation and progression of cancer. Notably, miR-155 is one of the most overexpressed miRNAs in several solid and hematological malignancies. Ectopic miR-155 expression in mice B cells (Eμ-miR-155 transgenic mice) has been shown to induce pre-B-cell proliferation followed by high-grade lymphoma/leukemia. Loss of miR...

2017
Ahmed M. L. Bedewy Shereen M. Elmaghraby Ahmed A. Shehata Noha S. Kandil

OBJECTIVE MicroRNA-155 (miRNA-155) resides within the B-cell integration cluster gene on chromosome 21. It can act either as an oncogene or as a tumor-suppressor gene, depending on the cell background in which miRNA-155 is performing its specific target gene controlling function. Therefore, the aim of this study was to investigate miRNA-155 expression in patients with B-cell non-Hodgkin lymphom...

Journal: :Journal of lipid research 1995
C A Dyer D P Cistola G C Parry L K Curtiss

Apolipoprotein (apo) E, via its receptor binding domain contained in residues 140-150, mediates hepatic and peripheral tissue binding of cholesterol-rich lipoproteins. Previously, we reported that a synthetic peptide representing a linear tandem repeat of amino acids 141-155, the 141-155 dimer, binds the low density lipoprotein (LDL) receptor. To define the structural features essential for LDL...

2017
Wei‐Lin Zhang Yu‐Fei Chen Hong‐Zheng Meng Jun‐Jie Du Guan‐Nan Luan Hai‐Qiang Wang Mao‐Wei Yang Zhuo‐Jing Luo

The molecular mechanisms of intervertebral disc degeneration (IDD) remain elusive. We found that miR-155 is down-regulated in degenerative nucleus pulposus (NP), and more severe degeneration is correlated with higher matrix metallopeptidase 16 (MMP-16) expression. MMP-16 also degraded matrix aggrecan. Here, we addressed the in vivo miR-155-mediated pathological impact on IDD using a classic pun...

2018
Edith Schneider Anna Staffas Linda Röhner Erik D. Malmberg Arghavan Ashouri Kathrin Krowiorz Nicole Pochert Christina Miller Stella Yuan Wei Laleh Arabanian Christian Buske Hartmut Döhner Lars Bullinger Linda Fogelstrand Michael Heuser Konstanze Döhner Ping Xiang Jens Ruschmann Oleh I. Petriv Alireza Heravi-Moussavi Carl L. Hansen Martin Hirst R. Keith Humphries Arefeh Rouhi Lars Palmqvist Florian Kuchenbauer

Micro-ribonucleic acid-155 (miR-155) is one of the first described oncogenic miRNAs. Although multiple direct targets of miR-155 have been identified, it is not clear how it contributes to the pathogenesis of acute myeloid leukemia. We found miR-155 to be a direct target of Meis1 in murine Hoxa9/Meis1 induced acute myeloid leukemia. The additional overexpression of miR-155 accelerated the forma...

2015
Alessia Burocchi Paola Pittoni Esmerina Tili Alice Rigoni Stefan Costinean Carlo Maria Croce Mario Paolo Colombo

Invariant natural killer T cells (iNKT cells) are CD1d-restricted, lipid antigen-reactive T lymphocytes with immunoregulatory functions. iNKT cell development in the thymus proceeds through subsequent stages, defined by the expression of CD44 and NK1.1, and is dictated by a unique gene expression program, including microRNAs. Here, we investigated whether miR-155, a microRNA involved in differe...

Journal: :Molecular medicine reports 2016
Ying-Chun Wan Tao Li Yang-Dong Han Hai-Yan Zhang Hai Lin Bin Zhang

Colorectal carcinoma (CRC) is a malignant solid tumor arising from the large intestine and is associated with an increasing incidence and poor prognosis. Further understanding of the molecular mechanisms underlying CRC may contribute to the development of novel effective therapeutic strategies. MicroRNAs (miRs), including miR‑155, have been reported to be associated with the etiology and biolog...

2014
KERRY E. SIEH

_______________________________ 155 Introduction ______________________________ 155 Observations _______________________________ 155 Comparison with 1968 slippage __________________ 157 Similarities ______________________________ 157 Differences ________________________________ 157 Discussion ________________________________ 157 Acknowledgments -_________________________^_ 159 References cited ...

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