West Syndrome is characterized by infantile spasms, a hypsarrhythmic electroencephalogram (EEG) pattern, and a poor neurodevelopmental prognosis. First-line treatments include adrenocorticotrophic hormone (ACTH) and vigabatrin, but adverse effects often limit their use. CPP-115 is a high-affinity vigabatrin analogue developed to increase therapeutic potency and to limit retinal toxicity. Here, ...

The roles of actin-binding proteins in development and morphogenesis are not well understood. The actin-binding protein UNC-115 has been implicated in cytoskeletal signaling downstream of Rac in Caenorhabditis elegans axon pathfinding, but the cellular role of UNC-115 in this process remains undefined. Here we report that UNC-115 overactivity in C. elegans neurons promotes the formation of neur...

JERRY SWAN1, GABRIELA OCHOA1, GRAHAM KENDALL1, MARTIN EDJVET2 1Automated Scheduling, Optimisation and Planning (ASAP) Research Group, School of Computer Science and Information Technology, University of Nottingham, Jubilee Campus, Wollaton Road, Nottingham NG8 1BB, UK. Tel.: (+44) (0)115 846 6504, Fax: +44 (0)115 846 7877. 2School of Mathematical Sciences, University of Nottingham, University P...

Shionogi Carcinoma 115 cells (SC 115 cells) and Chiba Subline 2 cells (CS 2 cells) are clones of an androgen-responsive mouse tumor cell line and its autonomous subline, respectively. Since it was reported that the growth of cells from SC 115 was regulated by an androgen-induced fibroblast growth factor (FGF)-like peptide (1), the present study was aimed at examining whether a similar growth fa...