Background. All children with urinary tract infections (UTIs) should undergo imaging of the urinary tract. The Royal College of Radiologists currently recommends that such children should be referred to a paediatric specialist prior to imaging. Aim. To investigate whether direct referral of such children by general practitioners (GPs) for imaging offers advantages over the traditional approach....

Toll-like receptor 9 (TLR-9) recognizes unmethylated CpG dinucleotides which are abundant in prokaryotic DNA and yet are rare in eukaryotic DNA. Little is known about the significance of TLR-9 in terms of recognition of different bacterial DNA species. In this study HEK293 cells stably transfected with human TLR-9 were used to analyze the immunostimulatory properties of 15 bacterial DNA prepara...

The aim of the study was to assess the organoleptic differences of Clarias gariepinus smoked with two different energy sources, Anogeissus leiocarpus and Tamarindus indica with the help of a hedonic scale and to determine possible proximate composition difference between the smoked products. Smoking of the fishes was carried out for 4 hours using traditional smoking kiln, the chemical analysis ...

Computed tomography (CT) currently has the greatest sensitivity and specificity of imaging modalities used for the diagnosis of renal colic. When compared with ultrasound, non–contrast-enhanced CT is more sensitive in identifying obstructing ureteral stones and more accurate in measuring stone size. CT also more consistently locates the specific site of obstruction along the course of the urete...

Mild COPD is an asymptomatic disease but as oxidant antioxidant imbalance increases the severity of the disease also increases. The aim of the present study was to evaluate the oxidant antioxidant imbalance in mild and moderate COPD groups. The present study included 73 patients with COPD out of which 32 were of Mild impairment and 41 were suffering from Moderate COPD. The results indicated tha...

Prasugrel is a thienopyridine antiplatelet prodrug that undergoes rapid hydrolysis in vivo to a thiolactone metabolite by human carboxylesterase-2 (hCE2) during gastrointestinal absorption. The thiolactone metabolite is further converted to a pharmacologically active metabolite by cytochrome P450 isoforms. The aim of the current study was to elucidate hydrolases other than hCE2 involved in the ...

The central nervous system (CNS) has very restricted intrinsic regeneration ability under the injury or disease condition. Innovative repair strategies, therefore, are urgently needed to facilitate tissue regeneration and functional recovery. The published tissue repair/regeneration strategies, such as cell and/or drug delivery, has been demonstrated to have some therapeutic effects on experime...