Despite mixed results with laboratory animals, recent studies indicate that elevated intake of fluoride in drinking water may, depending on circumstances, cause high blood pressure (hypertension) in humans. Although primary or essential hypertension has various causes and is known to be associated with higher levels of vasoconstrictors like endothelin 1 and thromboxane 2, increased oxidative st...

Study #1: We specifically examined resistance artery function from the mesentery, because vasosonstriction of this vascular bed is important for orthostatic tolerance, and because others have reported that there is reduced ability to constrict this vascular bed after hindlimb suspension (McDonald et al., J. Appl. Physiol. 72: 2210-2218, 1992; Overton & Tipton, J. Appl. Physiol. 68: 355-362, 199...

Tetryzoline(TH) is an adrenergic agent (vasoconstrictors) and derived from imidazoline. This compound is closely related to naphazoline hydrochloride in its pharmacological action. Nanotechnology has been used to provide advanced biomedical research tools in drug delivery. The fullerene family especially C60 derivatives have appealing photo-, electro-chemical and physical properties for biomedi...

The main consequence of subarachnoid hemorrhage, for those who survive bleeding, is delayed, persistent vasospasm of intracranial conduit arteries which occurs between the third and seventh day after the insult and results in symptomatic brain ischemia in about 40% of cases. This vasospasm is considered to be a major cause of disability of post-SAH patients. Despite extensive experimental and c...

BACKGROUND Poor control of blood glucose in diabetes is known to promote vascular dysfunction and hypertension. Diabetes was recently shown to be linked to an increased prevalence of pulmonary hypertension. The aim of this study was to determine how the pharmacological reactivity of intrapulmonary arteries is altered in a rat model of diabetes. METHODS Diabetes was induced in rats by the beta...

To determine whether simulated microgravity in rats is associated with vascular dysfunction, we measured responses of isolated, pressurized mesenteric resistance artery segments (157- to 388-microm ID) to vasoconstrictors, pressure, and shear stress after 28-day hindlimb suspension (HS). Results indicated no differences between HS and control (C) groups in 1) sensitivity or maximal responses to...