PURPOSE The goal of this analysis was to determine the test-retest variability of functional and structural measures from a cohort of patients with advanced forms of Stargardt Disease (STGD) participating in the SAR422459 (NCT01367444) gene therapy clinical trial. METHODS Twenty-two participants, aged 24 to 66, diagnosed with advanced forms of STGD, with at least one pathogenic ABCA4 mutation...

Inflammatory fibroid polyp (Vanek tumor) is a rare benign lesion which originates from the submucosa of the gastrointestinal tract. The most common locatization is the gastric antrum. Although the etiopathogenesis is unknown, it is thought that inflammatory fibroid polyps are the result of reactive inflammatory processes because of their eosinophilrich stroma. Microscopically, fibrous connectiv...

Several works published over the last two decades have shown for a stylized set-up with homogeneous users that metering-based priority (MBP) schemes may generate Pareto improving departure time adjustments similar to those induced by congestion pricing, but without any financial transaction. We investigate whether MBP (i) still generates significant savings and (ii) remains Pareto-improving, va...

Transit planners need cost-effective ways of evaluating a wide range of alternatives relatively quickly, in order to identify potential transit systems that are likely to offer the greatest benefits for a given cost. In this paper, we describe a sketch transit planning model for the Washington DC region that is based on the Metropolitan Planning Organization’s travel demand model structure and ...

First-best pricing or assignment of property rights for rival and non-excludable goods is often infeasible. In a second-best setting where the social planner cannot limit total use, we show common-property resources can be over or under-consumed. This depends on whether the external benefits of reallocating users to less congested goods outweigh the additional costs imposed by new entrants. App...

We undertook a study to determine if the automatic detection and counting of vehicle passengers is feasible. An automated passenger counting system would greatly facilitate the operation of freeway lanes reserved for car-pools (HOV lanes). In the present paper we report our findings regarding the appropriate sensor phenomenology and arrangement for the task. We propose a novel system based on f...

Abstract Tunnels on freeways, as one of the critical bottlenecks, frequently cause severe congestion and passenger delay. To solve tunnel bottleneck problem, most existing research can be divided into two types. One is to adopt Variable Speed Limits (VSL) regulate a predetermined speed for vehicles get through smoothly. The other High-Occupancy Vehicle (HOV) lane management. In HOV management s...

A method for mining frequent patterns of individual user trajectories is proposed based on location semantics. The semantic trajectory obtained by inverse geocoding and preprocessed to obtain the Top-k candidate item sets, then spatio-temporal sequence intersection divide conquer merge methods are used convert iterative calculation long itemsets into hierarchical sets' regular operations, super...