Combination of three complementary imaging technologies ultrasound imaging, elastography, and optoacoustic imaging is suggested for detection and diagnostics of tissue pathology including cancer. The fusion of these ultrasound-based techniques results in a novel imaging system capable of simultaneous imaging of the anatomy (ultrasound imaging), cancer-induced angiogenesis (optoacoustic imaging)...

Ultrasound is a widely available, cost-effective, real-time, non-invasive and safe imaging modality widely used in the clinic for anatomical and functional imaging. With the introduction of novel molecularly-targeted ultrasound contrast agents, another dimension of ultrasound has become a reality: diagnosing and monitoring pathological processes at the molecular level. Most commonly used ultras...

Ultrasound imaging utilizes the interaction of sound waves with living tissue to produce an image of the tissue or, in Doppler-based modes, determine the velocity of a moving tissue, primarily blood. These dynamic, real time images can be analyzed to obtain quantitative structural and functional information from the target organ. This versatile, noninvasive diagnostic tool is widely used and ac...

Since the introduction of medical ultrasound in the 1950s, modern diagnostic ultrasound has progressed to see many major diagnostic tools come into widespread clinical use, such as B-mode imaging, color-flow imaging, and spectral Doppler. New applications, such as panoramic imaging, three-dimensional imaging, and quantitative imaging, are now beginning to be offered on some commercial ultrasoun...

Over the last few years, a large number of studies have emphasized the fundamental role of ultrasonography (US) in the clinical evaluation of patients affected by rheumatic disorders. However, not all rheumatic diseases have been studied by US. To date, very few reports exist on the use of US in the assessment of articular, periarticular structures and blood vessels in vasculitis. In this revie...

The present review provides an update of the available data and discusses research issues relating to ultrasound (US) imaging in osteoarthritis (OA). Currently, the principal indications for using US in OA include: delineation of changes within articular cartilage (AC) and demonstration of synovial and adjacent soft tissue pathology together with injection into OA joints under US guidance. US h...

A hybridized dual-imaging system combining real-time ultrasound imaging and MRI was utilized for cardiac imaging at 1.5 T and 3 T. The ultrasound scanner with a programmable software interface was connected via computer to the MRI scanner. Electronic noise was eliminated with electromagnetic shielding and grounding to the screen room. At 3 T, real-time prospective motion compensation in dynamic...

Molecular targeting of contrast agents for ultrasound imaging is emerging as a new medical imaging modality. It combines advances in ultrasound technology with principles of molecular imaging, thereby allowing non-invasive assessment of biological processes in vivo. Preclinical studies have shown that microbubbles, which provide contrast during ultrasound imaging, can be targeted to specific mo...

Acousto-optic imaging promises to provide in vivo images of optical contrast but with the superior spatial resolution of ultrasound imaging. Here we present novel quadrature detection of ultrasound-modulated photons with a gainmodulated, image-intensified, CCD camera. The additional detection of ultrasound-modulated fluorescence photons demonstrates potential for in vivo acousto-optic molecular...

Acousto-optic imaging promises to provide in vivo images of optical contrast but with the superior spatial reso-lution of ultrasound imaging. Here we present novel quadrature detection of ultrasound-modulated photons with a gain-modulated, image-intensified, CCD camera. The additional detection of ultrasound-modulated fluorescence photons dem-onstrates potential for in vivo acousto-...