نتایج جستجو برای: u266

تعداد نتایج: 289  

1997
Robert G. Hawley

Type I interferons (IFNs-a and IFN-b) bind to a common redownregulated IL-6–induced tyrosine phosphorylation of gp130, Jak2, PTP1D/Syp, Shc, and Erk2, and GTP-loading of ceptor to exert strong antiproliferative activity on a broad range of cell types, including interleukin-6 (IL-6)–dependent p21. Further analysis indicated that treatment with IFN-b disrupted IL-6–induced binding of PTP1D/Syp to...

Journal: :Blood 1997
L C Berger R G Hawley

Type I interferons (IFNs-alpha and IFN-beta) bind to a common receptor to exert strong antiproliferative activity on a broad range of cell types, including interleukin-6 (IL-6)-dependent myeloma cells. In this study, we investigated the effect of IFN-beta pretreatment on IL-6-stimulated mitogenic signaling in the human myeloma cell line U266. IL-6 induced transient tyrosine phosphorylation of t...

2014
Mohamed-Amine Hamouda Nathalie Belhacene Alexandre Puissant Pascal Colosetti Guillaume Robert Arnaud Jacquel Bernard Mari Patrick Auberger Frederic Luciano

Velcade is one of the inescapable drug to treat patient suffering from multiple myeloma (MM) and resistance to this drug represents a major drawback for patients. However, the mechanisms underlying velcade resistance remain incompletely understood. We derived several U266 MM cell clones that resist to velcade. U266-resistant cells were resistant to velcade-induced cell death but exhibited a sim...

Journal: :Blood 2005
Qing Chen Pieter C Van der Sluis David Boulware Lori A Hazlehurst William S Dalton

Melphalan, a DNA cross-linker, is one of the most widely used and effective drugs in the treatment of multiple myeloma (MM). In this report, we demonstrate that enhanced interstrand cross-link (ICL) repair via the Fanconi anemia (FA)/BRCA pathway contributes to acquired drug resistance in melphalan-resistant myeloma cell lines, and disruption of this pathway reverses drug resistance. Using the ...

2017
Yun-Feng Fu Xiao Liu Meng Gao Ya-Nan Zhang Jing Liu

We investigated the effects of endoplasmic reticulum stress (ERS) on autophagy, proliferation, apoptosis, and drug resistance in multiple myeloma (MM). MM patients enrolled in our study (n = 268) were classified into sensitive and resistant groups based on chemotherapy efficacy, and their serum levels of β2-MG, albumin (ALB), lactic dehydrogenase (LDH), Ca2+ and hemoglobin were determined. In a...

2017
Ping Liu Xue Wu Lu Dai Zheng Ge Chong Gao Hongming Zhang Fei Wang Xiaoping Zhang Baoan Chen

Hypoxia is an inseparable component of the bone marrow (BM) microenvironment, accounting for aggressive tumor behavior and poor prognosis of multiple myeloma (MM). Gambogenic acid (GNA) has proven to be an attractive option for treatment of tumors due to its tumor suppressive activity. Herein, we found that GNA exhibits remarkable apoptotic activity against MM cells even under hypoxia. MicroRNA...

Journal: :Molecular cancer therapeutics 2010
Felix G Meinel Sonja Mandl-Weber Philipp Baumann Johann Leban Ralf Schmidmaier

Evidence is increasing that aberrant NF-kappaB activation is crucial for multiple myeloma pathophysiology and a promising target for new antimyeloma therapies. In this study, we assessed the in vitro antimyeloma activity of the novel NF-kappaB inhibitor V1810. Pharmacokinetics and toxicity were studied in vivo. In mice, V1810 plasma concentrations of 10 micromol/L can be reached without relevan...

Journal: :Molecular medicine reports 2011
Jun Peng Youqin Chen Jiumao Lin Qunchuan Zhuang Wei Xu Zhenfeng Hong Thomas J Sferra

Signal transducer and activator of transcription 3 (STAT3) plays an important role in tumor cell survival and proliferation and thus has become a major focus in the development of anti-cancer therapies. Patrinia scabiosaefolia has been used for the treatment of various types of cancer. However, the precise mechanism of the anti-cancer activity of Patrinia scabiosaefolia remains unclear. In this...

Journal: :Oncology reports 2010
Hai-Ying Fu Jian-Zhen Shen Yong Wu Song-Fei Shen Hua-Rong Zhou Li-Ping Fan

Cyclin-dependent kinase inhibitors CDKN2B and CDKN2A are tumor suppressor genes that are frequently dysregulated in a variety of cancers. Aberrant regulation via DNA hypermethylation causes gene silencing. Arsenic trioxide has been successfully used to treat malignant, hematopoietic diseases and is known to act by induction of apoptosis and inhibition of cellular proliferation. However, arsenic...

Journal: :Blood 2004
Chor-Sang Chim Tsz-Kin Fung Wai-Chung Cheung Raymond Liang Yok-Lam Kwong

SOCS1 and SHP1 negatively regulate the Janus kinase/signal transducer and activator of transcription (Jak/STAT) signaling pathway. The role of promoter hypermethylation leading to epigenetic inactivation of SOCS1 and SHP1 in myeloma was investigated. The methylation-specific polymerase chain reaction (MSP) was used to define SOCS1 and SHP1 methylation in 34 diagnostic myeloma samples. For SOCS1...

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