BACKGROUND NXL104 is a novel-structure beta-lactamase inhibitor with potent activity against both class A and class C enzymes. Among the class A carbapenemases, KPC-type enzymes are now spreading rapidly and KPC-related carbapenemase resistance is an emerging phenomenon of great clinical importance. The activity of NXL104 against KPC beta-lactamases was examined. METHODS Enzymatic activity of...

Singapore is an international travel and medical hub and faces a genuine threat for import and dissemination of bacteria with broad-spectrum resistance. In this review, we described the current landscape and management of carbapenem resistance in Gram-negative bacteria (GNB) in Singapore. Notably, the number of carbapenem-resistant Enterobacteriaceae has exponentially increased in the past two ...

Abstract Background Infections are common complications in patients with cancer. Data on antimicrobial resistance is important to guide empirical therapy. However, rates varies among different regions and countries and, general, higher Latin America. There limited data from these this region. The aim of work determine the frequency antibiotic susceptibility profiles, as well identify most frequ...

The antibiotic susceptibility of 125 P. aeruginosa isolated from 215 clinical samples (blood, urine, wound swab samples, sputum, and cerebrospinal fluid) was determined using the disk diffusion method on Muller-Hinton agar medium. results showed that isolates had a high resistance rate to carbenicillin (83.2%) piperacillin (76%). Resistance imipenem meropenem were 7.4% 14.8%, respectively, whil...

We aimed to describe the in vivo activity of humanized pharmacokinetic exposures of meropenem and comparators against Verona integron-encoded metallo-β-lactamase (MBL) (VIM)-producing Enterobacteriaceae in a murine model. Levofloxacin activity was predicted by its MIC, and cefepime activity displayed variability, whereas meropenem produced a >1 log CFU reduction against all isolates despite hig...

The molecular epidemiology and mechanisms of resistance of carbapenem-resistant Enterobacteriaceae (CRE) were determined in hospitals in the countries of the Gulf Cooperation Council (GCC), namely, Saudi Arabia, United Arab Emirates, Oman, Qatar, Bahrain, and Kuwait. Isolates were subjected to PCR-based detection of antibiotic-resistant genes and repetitive sequence-based PCR (rep-PCR) assessme...

BACKGROUND Resistance to carbapenems is a significant therapeutic threat. The increasing frequency of car bapenemase enzymes among Gram-negative bacilli makes their early detection and differentiation urgent. Carbapenemases belonging to Class A are most commonly produced by members of family Enterobacteriaceae and are inhibited to various degrees by clavulanic acid. The present study is aimed t...

Antimicrobial resistance has emerged as a major danger to contemporary medicine around the world. Carbapenems are highest class of B-lactam drugs which considered most effective and safest antibiotics available. Increasing spread carbapenemases been noted across world restricts treatment options. The aim this study was determine incidence carbapenem resistant genotypic pathways in tertiary care...

INTRODUCTION Carbapenemases have increasingly been reported in enterobacteriaceae worldwide. Most carbapenemases are plasmid encoded hence resistance can easily spread. Carbapenem-resistant enterobacteriaceae are reported to cause mortality in up to 50% of patients who acquire bloodstream infections. We set out to determine the burden of carbapenem resistance as well as establish genes encoding...

Objectives Detection of rarer carbapenemases is challenging, as it requires molecular assays with comprehensive coverage or the use of phenotypic methods for the detection of carbapenemase activity. We describe a new class A carbapenemase, FRI-2, in an Enterobacter cloacae complex isolate following implementation of an in-house multiplex PCR for the detection of 'rare' class A carbapenemases. ...