Several months after left radical mastectomy without irradiation therapy for breast cancer, a 74-year-old woman developed severe edema on the homolateral arm extending to the axilla. Ten years later, purplish to brownish blotch and nodules accompanied with heating sensation and pain appeared and increased in size gradually on the left forearm. The patient was treated by irradiation therapy unde...

Several randomized trials have shown that breast-conserving therapy (BCT) is as effective as mastectomy and should be a standard treatment for early-stage breast cancer. Recently, there has been an increase in reports of angiosarcoma (AS) after BCT. Herein, we report a case of AS which developed after BCT and a case of Stewart-Treves syndrome with a focus on lymphedema. Chronic lymphedema is th...

Angiosarcoma is a malignant endothelial tumor that can form in any part of the body, including the skin. It is known as hemangiosarcoma or lymphangiosarcoma, depending on whether it derives from the endothelium of the blood vessels or the lymph vessels, respectively. It was first described in 1948 by Stewart and Treves in a series of 6 cases of lymphangiosarcoma after chronic postmastectomy lym...

1
 Gain of function of the immune system caused by a ryanodine receptor 1 mutation 1
 2
 Mirko Vukcevic, Francesco Zorzato, Simone Keck, Dimitrios A. Tsakiris, Jennifer 3
 Keiser, Rick M. Maizels and Susan Treves 4
 5
 Departments of Anaesthesia and Biomedicine, Basel University Hospital, Hebelstrasse 6
 20, 4031 Basel, Switzerland; Department of Life Sciences and Biotechnology, 7
 University o...

Le syndrome de Stewart-Treves (SST) est une entité rare, correspondant à un angiosarcome cutané compliquant un lymphoedème chronique. Il est de mauvais pronostic. Stewart et Treves ont rapportés en 1948, les premiers cas d'angiosarcome secondaire à un traitement du cancer du sein. Ce terme s'est généralisé pour regrouper l'ensemble des cas de lymphangiosarcome sur lymphoedème d'origine congénit...

Stewart-treves syndrome (SST), also known as cutaneous angiosarcoma, is a rare and extremely serious complication of chronic lymphedema. Diagnosis is based on histology and immunohistochemistry. Treatment is primarily surgical. This syndrome occurs in 90% of cases after breast surgery. However, it can sometimes occur from other causes, as illustrated in our case study. The prognosis of Stewart-...