نتایج جستجو برای: tolbutamide
تعداد نتایج: 836 فیلتر نتایج به سال:
Irradiation of sulfonamide derived oral antidiabetic drug, tolbutamide (N-[(butylamino) carbonyl]-4methylbenzenesulfonamide,1) in a phosphate buffered solution under aerobic atmosphere afforded two photoproducts by cleavage of S-N and C (O)-N bonds of urea units. When irradiated with linoleic acid it photoinduced lipid peroxidation. The insignificant decrease in lipid peroxidation test under ar...
Tolbutamide, one of the hypoglycemic sulphonylurea drugs was fcund to decrease the respiratory control index of beef heart mitochondria as well as that of rat liver mitochondria. The effect of the drug on beef heart mitochondria was more pronounced than on liver mitochondria in the r an ge of concentrations of 30-80 mg% . It was of interest to find that DNP release of mitochondrial respiration ...
Two pathways control glucose-induced insulin secretion (IS) by beta-cells. The triggering pathway involves ATP-sensitive potassium (K(ATP)) channel-dependent depolarization, Ca(2+) influx, and a rise in the cytosolic Ca(2+) concentration ([Ca(2+)](c)), which triggers exocytosis of insulin granules. The metabolic amplifying pathway augments IS without further increasing [Ca(2+)](c). The underlyi...
Application of the PKCYP-test to predict the amount of in vivo CYP2C11 using tolbutamide as a probe.
Previous reports have shown that the determination of drug metabolism capacity can be made by the pharmacokinetic estimation of the quantity of cytochrome P450 (CYP) in vivo (PKCYP-test), in which an apparent liver-to-blood free concentration gradient in vivo (qg) is introduced, which is useful for evaluating fluctuations of CYPIA2 in rats. The aim of the present study was to examine the applic...
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