INTRODUCTION Physicians frequently deal with procedures which require sedation of pediatric patients. Laceration repair is one of them. No study has been performed regarding the comparison between induction of sedation with sodium thiopental and ketamine in laceration repair. Therefore, the present study was aimed to comparison of induced sedation by rectal sodium thiopental and muscular inject...

the methanolic leaf extract of thuja occidentalis was evaluated for possible sedative activities in mice. sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and elevated-plus maze (epm) tests at 200mg/kg and 400 mg/kg.  the extract decreased the locomotor activity of mice in hole cross, open field and epm test and showed the remarkable resul...

introduction: physicians frequently deal with procedures which require sedation of pediatric patients. laceration repair is one of them. no study has been performed regarding the comparison between induction of sedation with sodium thiopental and ketamine in laceration repair. therefore, the present study was aimed to comparison of induced sedation by rectal sodium thiopental and muscular injec...

A general, simple, practical and convenient method has been described for the synthesis of anesthetic drug thiopental using thiourea in the presence of sodium ethoxide. Anesthetic drug of thiopental was prepared in two stages; during the first stage, the alkylation of mthyl cyanoacetate was performed which was then to be followed by cyclization. Alkylation of methyl cyanoacetate which was perfo...

In vitro effects of dihydroergotoxine, dihydroergosine, dihydroergotamine, alpha-dihydroergocriptine (ergot alkaloids), diazepam, methyl-beta-Carboline-3-carboxilate (beta-CCM), flumazenil (benzodiazepines), gamma-amino butyric acid (GABA) and thiopental (barbiturate) were studied on mouse brain (cerebrum minus cerebral cortex) benzodiazepine binding sites labeled with 3H-flunitrazepam. Specifi...

Thiopental, monosodium 5-ethyl-5(1-methylbutyl) -thiobarbiturate, is extensively used in clinical anesthesia either as a primary anesthetic agent for short surgical procedures or as a supplementary drug in conjunction with other anesthetics. Fatalities have been attributed to its use (1, 2) and cardiac arrest has occurred following its administration to patients under spinal anesthesia (3). Mos...

An accurate, sensitive, and specific gas-liquid-chromatographic procedure is described for determining concentrations of thiopental in human plasma. After a double extraction of 0.2 or 1.0 mL of plasma containing phenobarbital as an internal standard, thiopental and the internal standard are derivatized in a polar non-aqueous solvent system with iodomethane. The reaction mixture is then evapora...

Following a single administration of sodium thiopental in high doses (85 mg/kg intraperitoneally), the animals demonstrated absence or weakening reflexes at levels spinal cord, medulla oblongata, bridge and midbrain cerebral cortex over period one day. Other signs included pronounced hypothermia, decrease respiratory rate violation its rhythm, distinct tendency to bradycardia. On days 1-3 after...

BACKGROUND Current theories favour multiple agent-specific neuronal actions for both general anaesthetics and antiepileptic drugs, but the pharmacological properties that distinguish them are poorly understood. We compared the interactions of representative agents from each class on their putative targets using well-characterized radioligand binding assays. METHODS Synaptosomes or membranes p...