Summary Background In the United States, carrying capacity of land has been overwhelmed with wild horse and burro populations. Identification a long‐term contraception method is needed to control growing populations as current methods cannot quell these numbers. Sperm acrosome‐associated 3 protein (SPACA3) expressed in both male female reproductive systems. SPACA3 may prove be viable target hor...

Adiponectin is an adipose-secreted hormone that regulates energy homeostasis and is also involved in the control of the reproductive system. The goal of the present study was to investigate changes in adiponectin gene and protein expression in porcine ovarian structures during the oestrous cycle and to examine the effects of in vitro administration of adiponectin on basal and gonadotrophin- and...

The aim of the present study was to investigate the effects of glucose, galactose and fructose on the LH-induced differentiation and mRNA expression of sugar transport facilitators (SLC2A) by sheep thecal cells derived from small antral follicles cultured under serum-free conditions for 6 days. The dose and type of monosaccharide had a significant effect on LH-induced androstenedione production...

In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep. While, these ruminants appear to exhibit a relaxin-like physiology, as in other mammals, until now a molecular understanding of this has been lacking. Cloning and expression analy...

Background Gonadotropins induce follicular development that leads to ovulation and luteinization. In women, the level of gonadotropins, along with the expression of their receptors, changes dynamically throughout the menstrual cycle. This study aimed to clarify the mechanisms underlying these phenomena. Methods The literature was reviewed, including that published by the authors. Main findi...

Interaction partners of follicular cells play a significant role in steroidogenesis, follicular formation, and development. Androgen secreted by theca cells (TCs) can initiate follicle development and ovulation and provide precursor materials for estrogen synthesis. Therefore, studies on ovarian microenvironment will not only lead to better understanding of the steroidogenesis but also have cli...

The sites of action and the physiological role of estrogens and progesterone in the ovary are poorly understood in Reptiles. We have undertaken a systematic study of the immunoexpression of classical oestrogen receptor (ER or ERalpha) and progesterone receptor (PR) in the female lizard during the reproductive cycle. During vitellogenesis, ER was not expressed in vitellogenic follicles whereas P...

The kallikrein-kinin system (KKS) has been described as an important mediator of physiologic processes. Kallikreins use kininogen (KNG) as substrate to generate bradykinin, the main active peptide of the KKS that acts through two types of receptors, the B(1)R and the B(2)R. The goal of this study was to characterize some components of the KKS in different compartments of the ovary during the bo...

OBJECTIVE Congenital lipoid adrenal hyperplasia (lipoid CAH) results in impairment of adrenal and gonadal steroidogenesis caused by STAR mutations. Our previous study revealed upregulation of genes associated with inflammatory or immune response and macrophage infiltration in the adrenal cortex of Star-knockout mice. This study aimed at investigating macrophage infiltration in the gonads from h...

for the present study, and follow-up of histochemical changes in estradiol valerate-induced polycysticovary syndrome (pcos), 48 virgin 90-day-old female rats were used. the rats were divided into thetreatment and control groups. for each rat of the treatment group, 4 mg estradiol valerate was injectedthrough intramuscular route for the induction of pcos. the control group was taken the same amo...