نتایج جستجو برای: thalassemic

تعداد نتایج: 1036  

Journal: :BMC Blood Disorders 2002
Fabrizio Mastropietro Guido Modiano Maria Pia Cappabianca Enrica Foglietta Carmelo D'Asero Mauro Mezzabotta Donatella Ponzini Laura Maffei Antonio Amato Maria Lerone Paola Grisanti Paola Di Biagio Silvana Rinaldi Ida Bianco

BACKGROUND: The thalassemic syndromes originate from mutations of the globin genes that cause, besides the characteristic clinical picture, also an increased Hb F amount. It is not yet clear if there are more factors, besides the beta globin genotype, determining the Hb F production. We have tried to find out if there are relations between total Hb and Hb F, between erythropoietin (Epo) and Hb ...

Journal: :Blood 1998
F A Kuypers J Yuan R A Lewis L M Snyder C R Kiefer A Bunyaratvej S Fucharoen L Ma L Styles K de Jong S L Schrier

Phospholipid asymmetry in the red blood cell (RBC) lipid bilayer is well maintained during the life of the cell, with phosphatidylserine (PS) virtually exclusively located in the inner monolayer. Loss of phospholipid asymmetry, and consequently exposure of PS, is thought to play an important role in red cell pathology. The anemia in the human thalassemias is caused by a combination of ineffecti...

Journal: :Genetic Vaccines and Therapy 2008
Emmanuelle E Fabre Pascal Bigey Yves Beuzard Daniel Scherman Emmanuel Payen

BACKGROUND In situ production of a secreted therapeutic protein is one of the major gene therapy applications. Nevertheless, the plasmatic secretion peak of transgenic protein may be deleterious in many gene therapy applications including Epo gene therapy. Epo gene transfer appears to be a promising alternative to recombinant Epo therapy for severe anaemia treatment despite polycythemia was rea...

Journal: :Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2011
Fadhli Mohamed Sani Sazilah Ahmad Sarji Mehmet Bilgen

OBJECTIVES The purpose of this study was to test the hypothesis that quantitative ultrasound properties of the calcaneus in Southeast Asian children treated for thalassemia have different characteristics than those of their healthy counterparts and thereby can be used for assessing the risk of osteoporosis. METHODS Broadband ultrasound attenuation and the speed of sound were measured from gro...

Journal: :Blood 2001
D A Persons E R Allay D E Sabatino P Kelly D M Bodine A W Nienhuis

As initial human gene therapy trials for beta-thalassemia are contemplated, 2 critical questions important to trial design and planning have emerged. First, what proportion of genetically corrected hematopoietic stem cells (HSCs) will be needed to achieve a therapeutic benefit? Second, what level of expression of a transferred globin gene will be required to improve beta-thalassemic erythropoie...

2015
Saleh Sandoughdaran Seyed Moayed Alavian Heidar Sharafi Bita Behnava Shima Salimi Leila Mehrnoush Pegah Karimi Elizee Maryam Keshvari

BACKGROUND Most thalassemic patients with chronic hepatitis C virus (HCV) infection do not respond to therapy with pegylated interferon (Peg-IFN) plus ribavirin (RBV) due to hepatic siderosis and RBV dose reduction caused by RBV-induced anemia. OBJECTIVES In the present study, we recruited HCV genotype 1-infected thalassemic patients who had relapsed after a 48-week treatment with Peg-IFN plu...

2015
Pierre-Marc Villeneuve

Thalassemias are a geographically widespread group of genetic hemoglobinopathies characterized by defective globin production and hemolytic anemia [1]. Thalassemic patients are frequently transfusiondependent and this, in addition to heightened gastrointestinal avidity for iron, creates a propensity for iron overload [1]. Infection is a major cause of morbidity in thalassemic patients and is se...

A Taheri A.A Vahidi Y Niliyan

this prospective case-control study was carried out to evaluate the Prevalence of positive cases of anti-HCV Ab in 107 thalassemic patients  and 107 children without any previous history of blood transfusion as a control group.ELISA GENERATION II was used for serologic investigation and then positive cases were confiemed  by RIBA generation I.the average age of thalassemic patients was 9.2+_4.3...

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