phenobarbital is a phenobarbiturate used as a sedative, anticonvulsant, or hypnotic with the doses prescribed and can cause teratogenic effects. the goal of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by phenobarbital using ftir micro spectroscopy. the mice were injected with phenobarbital (120mg/...

PURPOSE To identify the types of malformations resulting from the administration of retinoic acid (RA) to Swiss mice on different days of pregnancy. METHODS Twenty-four pregnant Swiss mice were divided into 4 groups of 6 animals each. The experimental groups received a single intraperitoneal injection of RA (70 mg/kg) on gestational days 7, 8 and 9 (D7, D8 and D9), while control animals (C) r...

The teratogenicity of californium-252 (Cf-252) irradiation which generates approximately 70% 2.3 MeV fast neutron and 30% gamma rays was evaluated. A single whole body exposure of Cf-252 at various doses was given to pregnant rats on day 8 or 9 of pregnancy, followed by microscopic autopsy of the fetuses at the terminal stage of pregnancy to search for external and internal malformations. For c...

Exposure to a variety of chemicals is a hazard of daily life. Some of these chemicals have teratogenic potency and may lead to social problems. As an example, thalidomide was prescribed as a sedative and for morning sickness in the late 1950s and caused serious embryonic effects worldwide. To avoid these problems, the development of efficient techniques for the detection of teratogenic substanc...

OBJECTIVE Safety of Lippia citriodora, as a herbal remedy, in pregnancy has not yet been evaluated. This study aimed to identify the effect of L. citriodora aqueous extract on pregnancy outcome in mice. MATERIALS AND METHODS Timed-pregnant mice received doses of 0.5 g/kg/day L. citriodora aqueous extract or the vehicle control during organogenesis, intraperitoneally. Maternal body weights wer...

Abstract: Title: Teratogenic Effects of Intravitreal Injection of Bevacizumab in Pregnant Rat Models Aim: To investigate teratogenic effect of intravitreal injection of bevacizumab in pregnant rat model Methods: Twenty seven female Wistar rat were inseminated. Pregnant rats were divided into 6 groups (three groups as case and three as control groups). Each case and control groups divided accord...

Objectives: To assess the extent to which teratogenic drugs are prescribed during pregnancy and to investigate. the feasibility of an alert system at the point of prescription, in order to improve drug safety during pregnancy. Methods: We establish a reference list of teratogenic drugs by merging lists of teratogenic drugs published in the literature, extract drug prescriptions to pregnant wome...