This study was performed to investigate the changes of tear film and ocular surface in diabetic patients, as well as the ocular and systemic factors related to these changes. We assessed the scoring of keratoepitheliopathy, corneal sensitivity test, tear film break-up time (BUT), Schirmer test, and conjunctival impression cytology in 94 eyes of 47 patients with noninsulin-dependent diabetes mel...

PURPOSE Human tear film stability decreases with increasing age. In this study, the changes in meibum composition were measured in search of markers of tear film instability. METHODS (1)H NMR nuclear magnetic resonance (NMR) spectra of 43 normal donors aged 1 to 88 years were acquired. RESULTS Compared with meibum from adolescents and adults, meibum from infants and children contains less C...

This study was designed to explore the influence of long-term corneal contact lens (CL) wearing on the stability and quality of tear film in Qinghai. Thirty subjects with CL over five years and thirty myopia subjects without CL as control were recruited in our study. Basic tear secretion test, tear film break-up time (TBUT), and corneal fluorescein staining were determined. For further evaluati...

We study the drainage of the precorneal tear film in humans. A fluid dynamic model for the drainage of the aqueous layer is developed that includes the effects of evaporation and gravity. The model may be reduced to a single nonlinear partial differential equation for the thickness of the aqueous layer. The equation is solved numerically and accurate times for film rupture are obtained for phys...

RATIONALE Dry eye is the most prevalent condition seen by the ophthalmologist, in particular in elderly. The identification of new common risk factors (computer use and contact lens wear) extends the disease among the young people. The early diagnosis of dry eye is essential, but difficult, because the biochemical changes in tear film usually occur before any detectable signs. Due its advantage...

PURPOSE Allergic conjunctivitis (AC) has been reported to induce the instability of the tear film. The tear protein and the lipid layer play important roles in maintaining the tear film. The aim of this study was to quantify the alteration of the major tear protein components and a lipid related protein secretory type IIa phospholipase A2 (sPLA2-IIa) in tears of seasonal allergic conjunctivitis...

Schirmer's test and tear film break-up time (BUT) were studied in 56 eyes of patients with pterygium and compared with 50 eyes of normal healthy subjects representing the same age, sex and geographical distribution. Both the values were found to be significantly reduced in cases of pterygium indicating the inadequacy of tear film in these patients.

BACKGROUND AND OBJECTIVES The analysis of the interference patterns on the tear film lipid layer is a useful clinical test to diagnose dry eye syndrome. This task can be automated with a high degree of accuracy by means of the use of tear film maps. However, the time required by the existing applications to generate them prevents a wider acceptance of this method by medical experts. Multithread...

PURPOSE The purpose of this work was to examine the tear film proteome using a combination of one-dimensional (1D) and two dimensional (2D) gel electrophoresis and mass spectrometry-based techniques and to explore the effect of the tear collection methods on the tear proteome. METHODS Tear samples from eight normal non-contact lens wearing human subjects collected by Drummond glass microcapil...

Purpose. Numerous ocular side effects have been reported with the use of systemic isotretinoin therapy. Herein, we presented two contact lens user patients who did not have contact lens intolerance during systemic isotretinoin therapy. Methods. 25-year-old male and 20-year-old female patients with severe acne vulgaris who were using highly wettable silicone hydrogel contact lenses which increas...